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Osteoarthritic cartilage explants affect extracellular matrix production and composition in cocultured bone marrow-derived mesenchymal stem cells and articular chondrocytes

INTRODUCTION: In the present study, we established a novel in vitro coculture model to evaluate the influence of osteoarthritis (OA) cartilage explants on the composition of newly produced matrix and chondrogenic differentiation of human bone marrow-derived mesenchymal stem cells (BMSCs) and the phe...

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Detalles Bibliográficos
Autores principales: Leyh, Michaela, Seitz, Andreas, Dürselen, Lutz, Springorum, Hans-Robert, Angele, Peter, Ignatius, Anita, Grifka, Joachim, Grässel, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097830/
https://www.ncbi.nlm.nih.gov/pubmed/24916039
http://dx.doi.org/10.1186/scrt466