Cargando…

Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues

Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating...

Descripción completa

Detalles Bibliográficos
Autores principales: Madaan, Kanika, Kumar, Sandeep, Poonia, Neelam, Lather, Viney, Pandita, Deepti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
https://www.ncbi.nlm.nih.gov/pubmed/25035633
http://dx.doi.org/10.4103/0975-7406.130965
_version_ 1782326253808779264
author Madaan, Kanika
Kumar, Sandeep
Poonia, Neelam
Lather, Viney
Pandita, Deepti
author_facet Madaan, Kanika
Kumar, Sandeep
Poonia, Neelam
Lather, Viney
Pandita, Deepti
author_sort Madaan, Kanika
collection PubMed
description Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity.
format Online
Article
Text
id pubmed-4097927
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-40979272014-07-17 Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues Madaan, Kanika Kumar, Sandeep Poonia, Neelam Lather, Viney Pandita, Deepti J Pharm Bioallied Sci Review Article Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4097927/ /pubmed/25035633 http://dx.doi.org/10.4103/0975-7406.130965 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Madaan, Kanika
Kumar, Sandeep
Poonia, Neelam
Lather, Viney
Pandita, Deepti
Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title_full Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title_fullStr Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title_full_unstemmed Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title_short Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
title_sort dendrimers in drug delivery and targeting: drug-dendrimer interactions and toxicity issues
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/
https://www.ncbi.nlm.nih.gov/pubmed/25035633
http://dx.doi.org/10.4103/0975-7406.130965
work_keys_str_mv AT madaankanika dendrimersindrugdeliveryandtargetingdrugdendrimerinteractionsandtoxicityissues
AT kumarsandeep dendrimersindrugdeliveryandtargetingdrugdendrimerinteractionsandtoxicityissues
AT poonianeelam dendrimersindrugdeliveryandtargetingdrugdendrimerinteractionsandtoxicityissues
AT latherviney dendrimersindrugdeliveryandtargetingdrugdendrimerinteractionsandtoxicityissues
AT panditadeepti dendrimersindrugdeliveryandtargetingdrugdendrimerinteractionsandtoxicityissues