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Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues
Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/ https://www.ncbi.nlm.nih.gov/pubmed/25035633 http://dx.doi.org/10.4103/0975-7406.130965 |
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author | Madaan, Kanika Kumar, Sandeep Poonia, Neelam Lather, Viney Pandita, Deepti |
author_facet | Madaan, Kanika Kumar, Sandeep Poonia, Neelam Lather, Viney Pandita, Deepti |
author_sort | Madaan, Kanika |
collection | PubMed |
description | Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity. |
format | Online Article Text |
id | pubmed-4097927 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40979272014-07-17 Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues Madaan, Kanika Kumar, Sandeep Poonia, Neelam Lather, Viney Pandita, Deepti J Pharm Bioallied Sci Review Article Dendrimers are the emerging polymeric architectures that are known for their defined structures, versatility in drug delivery and high functionality whose properties resemble with biomolecules. These nanostructured macromolecules have shown their potential abilities in entrapping and/or conjugating the high molecular weight hydrophilic/hydrophobic entities by host-guest interactions and covalent bonding (prodrug approach) respectively. Moreover, high ratio of surface groups to molecular volume has made them a promising synthetic vector for gene delivery. Owing to these properties dendrimers have fascinated the researchers in the development of new drug carriers and they have been implicated in many therapeutic and biomedical applications. Despite of their extensive applications, their use in biological systems is limited due to toxicity issues associated with them. Considering this, the present review has focused on the different strategies of their synthesis, drug delivery and targeting, gene delivery and other biomedical applications, interactions involved in formation of drug-dendrimer complex along with characterization techniques employed for their evaluation, toxicity problems and associated approaches to alleviate their inherent toxicity. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4097927/ /pubmed/25035633 http://dx.doi.org/10.4103/0975-7406.130965 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Madaan, Kanika Kumar, Sandeep Poonia, Neelam Lather, Viney Pandita, Deepti Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title | Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title_full | Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title_fullStr | Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title_full_unstemmed | Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title_short | Dendrimers in drug delivery and targeting: Drug-dendrimer interactions and toxicity issues |
title_sort | dendrimers in drug delivery and targeting: drug-dendrimer interactions and toxicity issues |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097927/ https://www.ncbi.nlm.nih.gov/pubmed/25035633 http://dx.doi.org/10.4103/0975-7406.130965 |
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