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Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs
This study aimed to elucidate the roles of both angiotensin II (ANG II) receptors – type 1 (AT1Rs) and type 2 (AT2Rs) – separately and together in influencing hemodynamic effects of endogenously produced nitric oxide (NO) during postnatal development. In conscious, chronically instrumented lambs age...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Periodicals, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098750/ https://www.ncbi.nlm.nih.gov/pubmed/24872358 http://dx.doi.org/10.14814/phy2.12027 |
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author | Vinturache, Angela E. Smith, Francine G. |
author_facet | Vinturache, Angela E. Smith, Francine G. |
author_sort | Vinturache, Angela E. |
collection | PubMed |
description | This study aimed to elucidate the roles of both angiotensin II (ANG II) receptors – type 1 (AT1Rs) and type 2 (AT2Rs) – separately and together in influencing hemodynamic effects of endogenously produced nitric oxide (NO) during postnatal development. In conscious, chronically instrumented lambs aged ~1 week (8 ± 1 days, N = 8) and ~6 weeks (41 ± 2 days, N = 8), systolic, diastolic, and mean arterial pressure (SAP, DAP, MAP) and venous pressure (MVP), renal blood flow (RBF), and renal vascular resistance (RVR) were measured in response to the l‐arginine analog, l‐NAME after pretreatment with either the AT1R antagonist, ZD 7155, the AT2R antagonist, PD 123319, or both antagonists. The increase in SAP, DAP, and MAP by l‐NAME was not altered by either ATR antagonist in either age group. The increase in RBF after l‐NAME was, however, altered by both ATR antagonists in an age‐dependent manner, which was mediated predominantly through AT2Rs in newborn lambs. These findings reveal that there is an age‐dependent interaction between the renin–angiotensin (RAS) and the NO pathway in regulating renal but not systemic hemodynamics through both ATRs, whereas AT2Rs appear to be important in the renal hemodynamic effects of NO early in life. |
format | Online Article Text |
id | pubmed-4098750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wiley Periodicals, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-40987502014-08-06 Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs Vinturache, Angela E. Smith, Francine G. Physiol Rep Original Research This study aimed to elucidate the roles of both angiotensin II (ANG II) receptors – type 1 (AT1Rs) and type 2 (AT2Rs) – separately and together in influencing hemodynamic effects of endogenously produced nitric oxide (NO) during postnatal development. In conscious, chronically instrumented lambs aged ~1 week (8 ± 1 days, N = 8) and ~6 weeks (41 ± 2 days, N = 8), systolic, diastolic, and mean arterial pressure (SAP, DAP, MAP) and venous pressure (MVP), renal blood flow (RBF), and renal vascular resistance (RVR) were measured in response to the l‐arginine analog, l‐NAME after pretreatment with either the AT1R antagonist, ZD 7155, the AT2R antagonist, PD 123319, or both antagonists. The increase in SAP, DAP, and MAP by l‐NAME was not altered by either ATR antagonist in either age group. The increase in RBF after l‐NAME was, however, altered by both ATR antagonists in an age‐dependent manner, which was mediated predominantly through AT2Rs in newborn lambs. These findings reveal that there is an age‐dependent interaction between the renin–angiotensin (RAS) and the NO pathway in regulating renal but not systemic hemodynamics through both ATRs, whereas AT2Rs appear to be important in the renal hemodynamic effects of NO early in life. Wiley Periodicals, Inc. 2014-05-28 /pmc/articles/PMC4098750/ /pubmed/24872358 http://dx.doi.org/10.14814/phy2.12027 Text en © 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Vinturache, Angela E. Smith, Francine G. Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title | Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title_full | Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title_fullStr | Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title_full_unstemmed | Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title_short | Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
title_sort | angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098750/ https://www.ncbi.nlm.nih.gov/pubmed/24872358 http://dx.doi.org/10.14814/phy2.12027 |
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