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Processive DNA Demethylation via DNA Deaminase-Induced Lesion Resolution

Base modifications of cytosine are an important aspect of chromatin biology, as they can directly regulate gene expression, while DNA repair ensures that those modifications retain genome integrity. Here we characterize how cytosine DNA deaminase AID can initiate DNA demethylation. In vitro, AID ini...

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Detalles Bibliográficos
Autores principales:	Franchini, Don-Marc, Chan, Chun-Fung, Morgan, Hugh, Incorvaia, Elisabetta, Rangam, Gopinath, Dean, Wendy, Santos, Fatima, Reik, Wolf, Petersen-Mahrt, Svend K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4098905/ https://www.ncbi.nlm.nih.gov/pubmed/25025377 http://dx.doi.org/10.1371/journal.pone.0097754

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