Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening and In Vitro Validation

Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics rendering the treatment of infections very difficult. A main mechanism attributed to the resistance is the function of efflux pumps. MexAB-OprM and AcrAB-TolC are the tripartite efflux pump assemblies, responsible...

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Detalles Bibliográficos
Autores principales: Aparna, Vasudevan, Dineshkumar, Kesavan, Mohanalakshmi, Narasumani, Velmurugan, Devadasan, Hopper, Waheeta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099075/
https://www.ncbi.nlm.nih.gov/pubmed/25025665
http://dx.doi.org/10.1371/journal.pone.0101840

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