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Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?

OBJECTIVE: Apparent diffusion coefficient (ADC) values calculated through magnetic resonance imaging have been proposed as a useful tool to distinguish benign from malignant liver lesions. Most studies however included simple cysts in their analysis. Liver cysts are easy to diagnose, have very high...

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Autores principales: Testa, Maria Luiza, Chojniak, Rubens, Sene, Letícia Silva, Damascena, Aline Santos, Guimarães, Marcos Duarte, Szklaruk, Janio, Marchiori, Edson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099077/
https://www.ncbi.nlm.nih.gov/pubmed/25025151
http://dx.doi.org/10.1371/journal.pone.0101944
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author Testa, Maria Luiza
Chojniak, Rubens
Sene, Letícia Silva
Damascena, Aline Santos
Guimarães, Marcos Duarte
Szklaruk, Janio
Marchiori, Edson
author_facet Testa, Maria Luiza
Chojniak, Rubens
Sene, Letícia Silva
Damascena, Aline Santos
Guimarães, Marcos Duarte
Szklaruk, Janio
Marchiori, Edson
author_sort Testa, Maria Luiza
collection PubMed
description OBJECTIVE: Apparent diffusion coefficient (ADC) values calculated through magnetic resonance imaging have been proposed as a useful tool to distinguish benign from malignant liver lesions. Most studies however included simple cysts in their analysis. Liver cysts are easy to diagnose, have very high ADC values and their inclusion facilitates differentiation in the ADC values between benign and malignant liver lesions groups. We prospectively evaluated the ability of ADC values to differentiate metastatic liver lesions from all benign or only solid benign liver lesions. MATERIAL AND METHODS: Sixty-seven adult cancer patients with 188 liver lesions were evaluated. Lesions were categorized as metastatic or benign throughout imaging and clinical evaluation. One hundred and five (105) metastatic lesions and 83 benign lesions including hemangiomas (37), cysts (42), adenomas (2) and focal nodular hyperplasias (2) were evaluated. ADC values were calculated for each lesion utilizing two b values (0 and 600 sec/mm(2)). RESULTS: The average ADC value for cysts was 2.4×10(−3) mm(2)/sec (CI: 2.1–2.6), for solid benign lesions was 1.4×10(−3) mm(2)/sec (CI: 1.1–1.7) and for metastases was 1.0×10(−3) mm(2)/sec (CI: 0.8–1.3). There was a difference between the ADC values of metastases and benign solid lesions (p<0.0001). With the ADC value of 1.5×10(−3) mm(2)/sec as a cut off it is possible to distinguish metastatic from benign liver lesions, including cysts, with an accuracy of 78%. But to distinguish metastatic from benign solid liver lesions the best ADC cut off value was 1.2×10(−3) mm(2)/sec and the accuracy drops to 71%. CONCLUSIONS: ADC values proved to be helpful in the distinction between metastasis and benign solid hepatic lesions. But the exclusion of cysts in the analysis point out to a lower cut off value and lower accuracy than previously reported.
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spelling pubmed-40990772014-07-18 Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy? Testa, Maria Luiza Chojniak, Rubens Sene, Letícia Silva Damascena, Aline Santos Guimarães, Marcos Duarte Szklaruk, Janio Marchiori, Edson PLoS One Research Article OBJECTIVE: Apparent diffusion coefficient (ADC) values calculated through magnetic resonance imaging have been proposed as a useful tool to distinguish benign from malignant liver lesions. Most studies however included simple cysts in their analysis. Liver cysts are easy to diagnose, have very high ADC values and their inclusion facilitates differentiation in the ADC values between benign and malignant liver lesions groups. We prospectively evaluated the ability of ADC values to differentiate metastatic liver lesions from all benign or only solid benign liver lesions. MATERIAL AND METHODS: Sixty-seven adult cancer patients with 188 liver lesions were evaluated. Lesions were categorized as metastatic or benign throughout imaging and clinical evaluation. One hundred and five (105) metastatic lesions and 83 benign lesions including hemangiomas (37), cysts (42), adenomas (2) and focal nodular hyperplasias (2) were evaluated. ADC values were calculated for each lesion utilizing two b values (0 and 600 sec/mm(2)). RESULTS: The average ADC value for cysts was 2.4×10(−3) mm(2)/sec (CI: 2.1–2.6), for solid benign lesions was 1.4×10(−3) mm(2)/sec (CI: 1.1–1.7) and for metastases was 1.0×10(−3) mm(2)/sec (CI: 0.8–1.3). There was a difference between the ADC values of metastases and benign solid lesions (p<0.0001). With the ADC value of 1.5×10(−3) mm(2)/sec as a cut off it is possible to distinguish metastatic from benign liver lesions, including cysts, with an accuracy of 78%. But to distinguish metastatic from benign solid liver lesions the best ADC cut off value was 1.2×10(−3) mm(2)/sec and the accuracy drops to 71%. CONCLUSIONS: ADC values proved to be helpful in the distinction between metastasis and benign solid hepatic lesions. But the exclusion of cysts in the analysis point out to a lower cut off value and lower accuracy than previously reported. Public Library of Science 2014-07-15 /pmc/articles/PMC4099077/ /pubmed/25025151 http://dx.doi.org/10.1371/journal.pone.0101944 Text en © 2014 Testa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Testa, Maria Luiza
Chojniak, Rubens
Sene, Letícia Silva
Damascena, Aline Santos
Guimarães, Marcos Duarte
Szklaruk, Janio
Marchiori, Edson
Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title_full Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title_fullStr Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title_full_unstemmed Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title_short Is DWI/ADC a Useful Tool in the Characterization of Focal Hepatic Lesions Suspected of Malignancy?
title_sort is dwi/adc a useful tool in the characterization of focal hepatic lesions suspected of malignancy?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099077/
https://www.ncbi.nlm.nih.gov/pubmed/25025151
http://dx.doi.org/10.1371/journal.pone.0101944
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