Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents

A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine...

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Detalles Bibliográficos
Autores principales: Mohamed, M. S., Ali, S. A., Abdelaziz, D. H. A., Fathallah, Samar S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099110/
https://www.ncbi.nlm.nih.gov/pubmed/25054134
http://dx.doi.org/10.1155/2014/249780
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author Mohamed, M. S.
Ali, S. A.
Abdelaziz, D. H. A.
Fathallah, Samar S.
author_facet Mohamed, M. S.
Ali, S. A.
Abdelaziz, D. H. A.
Fathallah, Samar S.
author_sort Mohamed, M. S.
collection PubMed
description A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds.
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spelling pubmed-40991102014-07-22 Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents Mohamed, M. S. Ali, S. A. Abdelaziz, D. H. A. Fathallah, Samar S. Biomed Res Int Research Article A series of pyrrole and pyrrolopyrimidine derivatives were examined for their in vivo antihyperglycemic activity. Compounds Ia–c,e, and IVg showed promising antihyperglycemic activity equivalent to a well-known standard antihyperglycemic drug, Glimepiride (Amaryl, 4 mg/kg). In this paper, we examine and discuss the structure-activity relationships and antihyperglycemic activity of these compounds. Hindawi Publishing Corporation 2014 2014-06-26 /pmc/articles/PMC4099110/ /pubmed/25054134 http://dx.doi.org/10.1155/2014/249780 Text en Copyright © 2014 M. S. Mohamed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mohamed, M. S.
Ali, S. A.
Abdelaziz, D. H. A.
Fathallah, Samar S.
Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title_full Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title_fullStr Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title_full_unstemmed Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title_short Synthesis and Evaluation of Novel Pyrroles and Pyrrolopyrimidines as Anti-Hyperglycemic Agents
title_sort synthesis and evaluation of novel pyrroles and pyrrolopyrimidines as anti-hyperglycemic agents
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099110/
https://www.ncbi.nlm.nih.gov/pubmed/25054134
http://dx.doi.org/10.1155/2014/249780
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