Effects of an Oxycodone Conjugate Vaccine on Oxycodone Self-Administration and Oxycodone-Induced Brain Gene Expression in Rats

Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodone. Here, the vaccine's ability to prevent acq...

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Detalles Bibliográficos
Autores principales: Pravetoni, Marco, Pentel, Paul R., Potter, David N., Chartoff, Elena H., Tally, Laura, LeSage, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099132/
https://www.ncbi.nlm.nih.gov/pubmed/25025380
http://dx.doi.org/10.1371/journal.pone.0101807

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099132/
https://www.ncbi.nlm.nih.gov/pubmed/25025380
http://dx.doi.org/10.1371/journal.pone.0101807

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