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Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone
Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidon...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099167/ https://www.ncbi.nlm.nih.gov/pubmed/25061527 http://dx.doi.org/10.1155/2014/602390 |
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author | Dietrich-Muszalska, Anna Kopka, Justyna Kontek, Bogdan |
author_facet | Dietrich-Muszalska, Anna Kopka, Justyna Kontek, Bogdan |
author_sort | Dietrich-Muszalska, Anna |
collection | PubMed |
description | Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml). Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(−4), P = 1.6 × 10(−3), and P = 2.7 × 10(−3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(−8), P = 7.0 × 10(−6), and P = 3.0 × 10(−5), respectively. Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone. |
format | Online Article Text |
id | pubmed-4099167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40991672014-07-24 Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone Dietrich-Muszalska, Anna Kopka, Justyna Kontek, Bogdan Schizophr Res Treatment Research Article Background. Oxidative stress in schizophrenia may be caused partially by the treatment of patients with antipsychotics. The aim of the study was to establish the effects of polyphenol compounds derived from berries of Aronia melanocarpa (Aronox) on the plasma lipid peroxidation induced by ziprasidone in vitro. Methods. Lipid peroxidation was measured by the level of thiobarbituric acid reactive species (TBARS). The samples of plasma from healthy subjects were incubated with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) alone and with Aronox (5 ug/ml; 50 ug/ml). Results. We observed a statistically significant increase of TBARS level after incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) (after 24 h incubation: P = 7.0 × 10(−4), P = 1.6 × 10(−3), and P = 2.7 × 10(−3), resp.) and Aronox lipid peroxidation caused by ziprasidone was significantly reduced. After 24-hour incubation of plasma with ziprasidone (40 ng/ml; 139 ng/ml; and 250 ng/ml) in the presence of 50 ug/ml Aronox, the level of TBARS was significantly decreased: P = 6.5 × 10(−8), P = 7.0 × 10(−6), and P = 3.0 × 10(−5), respectively. Conclusion. Aronox causes a distinct reduction of lipid peroxidation induced by ziprasidone. Hindawi Publishing Corporation 2014 2014-06-25 /pmc/articles/PMC4099167/ /pubmed/25061527 http://dx.doi.org/10.1155/2014/602390 Text en Copyright © 2014 Anna Dietrich-Muszalska et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dietrich-Muszalska, Anna Kopka, Justyna Kontek, Bogdan Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title | Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title_full | Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title_fullStr | Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title_full_unstemmed | Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title_short | Polyphenols from Berries of Aronia melanocarpa Reduce the Plasma Lipid Peroxidation Induced by Ziprasidone |
title_sort | polyphenols from berries of aronia melanocarpa reduce the plasma lipid peroxidation induced by ziprasidone |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099167/ https://www.ncbi.nlm.nih.gov/pubmed/25061527 http://dx.doi.org/10.1155/2014/602390 |
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