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5-Lipoxygenase Activating Protein (FLAP) Dependent Leukotriene Biosynthesis Inhibition (MK591) Attenuates Lipid A Endotoxin-Induced Inflammation

The Lipid A moiety of endotoxin potently activates TLR-4 dependent host innate immune responses. We demonstrate that Lipid-A mediated leukotriene biosynthesis regulates pathogen-associated molecular patterns (PAMP)-dependent macrophage activation. Stimulation of murine macrophages (RAW264.7) with E....

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Detalles Bibliográficos
Autores principales:	Fang, Wen-Feng, Douglas, Ivor S., Wang, Chin-Chou, Kao, Hsu-Ching, Chang, Ya-Ting, Tseng, Chia-Cheng, Huang, Kuo-Tung, Chang, Huang-Chih, Lin, Meng-Chih
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099325/ https://www.ncbi.nlm.nih.gov/pubmed/25025775 http://dx.doi.org/10.1371/journal.pone.0102622

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