The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated TAU protein. Diabetic patients with dysregulated i...

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Detalles Bibliográficos
Autores principales: Hettich, Moritz M., Matthes, Frank, Ryan, Devon P., Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauß, Sybille, Ehninger, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099345/
https://www.ncbi.nlm.nih.gov/pubmed/25025689
http://dx.doi.org/10.1371/journal.pone.0102420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099345/
https://www.ncbi.nlm.nih.gov/pubmed/25025689
http://dx.doi.org/10.1371/journal.pone.0102420

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