Cargando…

The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex

Alzheimer’s disease (AD), the most common form of dementia in the elderly, is characterized by two neuropathological hallmarks: senile plaques, which are composed of Aβ peptides, and neurofibrillary tangles, which are composed of hyperphosphorylated TAU protein. Diabetic patients with dysregulated i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hettich, Moritz M., Matthes, Frank, Ryan, Devon P., Griesche, Nadine, Schröder, Susanne, Dorn, Stephanie, Krauß, Sybille, Ehninger, Dan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099345/ https://www.ncbi.nlm.nih.gov/pubmed/25025689 http://dx.doi.org/10.1371/journal.pone.0102420

Ejemplares similares

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex
por: Schweiger, Susann, et al.
Publicado: (2017)

Regulation of mRNA Translation by MID1: A Common Mechanism of Expanded CAG Repeat RNAs
por: Griesche, Nadine, et al.
Publicado: (2016)

Correction: The Anti-Diabetic Drug Metformin Reduces BACE1 Protein Level by Interfering with the MID1 Complex
Publicado: (2014)

Inhibition of the MID1 protein complex: a novel approach targeting APP protein synthesis
por: Matthes, Frank, et al.
Publicado: (2018)

Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome
por: Heinen, Markus, et al.
Publicado: (2012)

MicroRNAs miR-19, miR-340, miR-374 and miR-542 regulate MID1 protein expression
por: Unterbruner, Kristoffer, et al.
Publicado: (2018)

Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling
por: Perdigão, Catarina, et al.
Publicado: (2021)

High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice
por: Henzel, Kristin S., et al.
Publicado: (2017)

The MID1 Protein: A Promising Therapeutic Target in Huntington’s Disease
por: Heinz, Annika, et al.
Publicado: (2021)

Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease
por: Arnoux, Isabelle, et al.
Publicado: (2018)

Limited Effects of an eIF2α (S51A) Allele on Neurological Impairments in the 5xFAD Mouse Model of Alzheimer's Disease
por: Paesler, Katharina, et al.
Publicado: (2015)

BACE1 across species: a comparison of the in vivo consequences of BACE1 deletion in mice and rats
por: Weber, Martin, et al.
Publicado: (2017)

The antineoplastic drug metformin downregulates YAP by interfering with IRF-1 binding to the YAP promoter in NSCLC
por: Jin, Dan, et al.
Publicado: (2018)

Is It the Twilight of BACE1 Inhibitors?
por: Hrabinova, Martina, et al.
Publicado: (2021)

Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing
por: Zhao, Yonghao, et al.
Publicado: (2012)

The effect of BACE1-AS on β-amyloid generation by regulating BACE1 mRNA expression
por: Li, Fan, et al.
Publicado: (2019)

A tale of two drug targets: the evolutionary history of BACE1 and BACE2
por: Southan, Christopher, et al.
Publicado: (2013)

BACE1 and SCD1 are associated with neurodegeneration
por: Bedoya-Guzmán, Ferley A., et al.
Publicado: (2023)

Bison: bisulfite alignment on nodes of a cluster
por: Ryan, Devon Patrick, et al.
Publicado: (2014)

Developing BACE-1 inhibitors for FXS
por: Westmark, Cara J., et al.
Publicado: (2013)

Early elevation of BACE1 in dementia
por: Cervellati, Carlo, et al.
Publicado: (2021)

RCAN1 Inhibits BACE2 Turnover by Attenuating Proteasome-Mediated BACE2 Degradation
por: Qiu, Kaixin, et al.
Publicado: (2020)

PS1 Affects the Pathology of Alzheimer’s Disease by Regulating BACE1 Distribution in the ER and BACE1 Maturation in the Golgi Apparatus
por: Li, Nuomin, et al.
Publicado: (2022)

Amino Acid Sequence and Structural Comparison of BACE1 and BACE2 Using Evolutionary Trace Method
por: Mirsafian, Hoda, et al.
Publicado: (2014)

Mechanisms of RNA-induced toxicity in CAG repeat disorders
por: Nalavade, R, et al.
Publicado: (2013)

Evaluation of BACE1 Silencing in Cellular Models
por: Sierant, Malgorzata, et al.
Publicado: (2009)

Regulation of dynamic BACE1 trafficking in neurons
por: Buggia-Prévot, Virginie, et al.
Publicado: (2013)

Development and Structural Modification of BACE1 Inhibitors
por: Gu, Ting, et al.
Publicado: (2016)

Role of BACE1 in Alzheimer’s synaptic function
por: Das, Brati, et al.
Publicado: (2017)

Expression of BACE1 in the Rat Carotid Body
por: Li, Chaohong, et al.
Publicado: (2020)

Attenuated ability of BACE1 to cleave the amyloid precursor protein via silencing long noncoding RNA BACE1-AS expression
por: LIU, TE, et al.
Publicado: (2014)

pHluorin-BACE1-mCherry Acts as a Reporter for the Intracellular Distribution of Active BACE1 In Vitro and In Vivo
por: Zhao, Lu, et al.
Publicado: (2019)

Pharmacological BACE1 and BACE2 inhibition induces hair depigmentation by inhibiting PMEL17 processing in mice
por: Shimshek, Derya R., et al.
Publicado: (2016)

The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes
por: Keable, Ryan, et al.
Publicado: (2022)

BACE1-Dependent Neuregulin-1 Signaling: An Implication for Schizophrenia
por: Zhang, Zhengrong, et al.
Publicado: (2017)

BACE1 gene variants do not influence BACE1 activity, levels of APP or Aβ isoforms in CSF in Alzheimer's disease
por: Sjölander, Annica, et al.
Publicado: (2010)

The Alzheimer's disease β-secretase enzyme, BACE1
por: Cole, Sarah L, et al.
Publicado: (2007)

Palmitoylated APP Forms Dimers, Cleaved by BACE1
por: Bhattacharyya, Raja, et al.
Publicado: (2016)

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment
por: Coimbra, Judite R. M., et al.
Publicado: (2018)

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors
por: Green, Keith D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_q8vnavldhbib8ur0a0jb3cnq6k