PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells

Glucose and GLP-1 stimulate not only insulin secretion, but also the post-transcriptional induction of insulin granule biogenesis. This process involves the nucleocytoplasmic translocation of the RNA binding protein PTBP1. Binding of PTBP1 to the 3′-UTRs of mRNAs for insulin and other cargoes of bet...

Descripción completa

Detalles Bibliográficos
Autores principales: Knoch, Klaus-Peter, Nath-Sain, Suchita, Petzold, Antje, Schneider, Hendryk, Beck, Mike, Wegbrod, Carolin, Sönmez, Anke, Münster, Carla, Friedrich, Anne, Roivainen, Merja, Solimena, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099505/
https://www.ncbi.nlm.nih.gov/pubmed/25061557
http://dx.doi.org/10.1016/j.molmet.2014.05.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099505/
https://www.ncbi.nlm.nih.gov/pubmed/25061557
http://dx.doi.org/10.1016/j.molmet.2014.05.002

Ejemplares similares