Cargando…
ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload
Palmitate overload induces hepatic cell dysfunction characterized by enhanced apoptosis and altered citric acid cycle (CAC) metabolism; however, the mechanism of how this occurs is incompletely understood. We hypothesize that elevated doses of palmitate disrupt intracellular calcium homeostasis resu...
Autores principales: | Egnatchik, Robert A., Leamy, Alexandra K., Jacobson, David A., Shiota, Masakazu, Young, Jamey D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099508/ https://www.ncbi.nlm.nih.gov/pubmed/25061559 http://dx.doi.org/10.1016/j.molmet.2014.05.004 |
Ejemplares similares
-
Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
por: Zeng, Xin, et al.
Publicado: (2020) -
Correction to: Oleic acid ameliorates palmitic acid induced hepatocellular lipotoxicity by inhibition of ER stress and pyroptosis
por: Zeng, Xin, et al.
Publicado: (2020) -
Protopanaxadiol ameliorates palmitate-induced lipotoxicity and pancreatic β-cell dysfunction in INS-1 cells
por: Lee, Dahae, et al.
Publicado: (2023) -
The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction
por: Ge, Mengyuan, et al.
Publicado: (2020) -
Lipotoxicity of Palmitic Acid on Neural Progenitor Cells and Hippocampal Neurogenesis
por: Park, Hee Ra, et al.
Publicado: (2011)