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ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload

Palmitate overload induces hepatic cell dysfunction characterized by enhanced apoptosis and altered citric acid cycle (CAC) metabolism; however, the mechanism of how this occurs is incompletely understood. We hypothesize that elevated doses of palmitate disrupt intracellular calcium homeostasis resu...

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Detalles Bibliográficos
Autores principales:	Egnatchik, Robert A., Leamy, Alexandra K., Jacobson, David A., Shiota, Masakazu, Young, Jamey D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099508/ https://www.ncbi.nlm.nih.gov/pubmed/25061559 http://dx.doi.org/10.1016/j.molmet.2014.05.004

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