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No evidence of a longitudinal association between diurnal cortisol patterns and cognition()
We examined the effect of salivary cortisol on cognitive performance and decline in 3229 adults (79% men), mean age 61 years. Six saliva samples over the day along with a cognition test battery were administered twice in 5 years. In fully-adjusted cross-sectional analyses from 2002 to 2004, higher w...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099515/ https://www.ncbi.nlm.nih.gov/pubmed/24735831 http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.015 |
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author | Singh-Manoux, Archana Dugravot, Aline Elbaz, Alexis Shipley, Martin Kivimaki, Mika Kumari, Meena |
author_facet | Singh-Manoux, Archana Dugravot, Aline Elbaz, Alexis Shipley, Martin Kivimaki, Mika Kumari, Meena |
author_sort | Singh-Manoux, Archana |
collection | PubMed |
description | We examined the effect of salivary cortisol on cognitive performance and decline in 3229 adults (79% men), mean age 61 years. Six saliva samples over the day along with a cognition test battery were administered twice in 5 years. In fully-adjusted cross-sectional analyses from 2002 to 2004, higher waking cortisol was associated with higher reasoning score (β = 0.08, 95% confidence interval: 0.01, 0.15) but this finding was not replicated using data from 2007 to 2009. Over the mean 5 years follow-up there was decline in all cognitive tests but this decline did not vary as a function of cortisol levels; the exception was among APOE e4 carriers where a flatter diurnal slope and higher bedtime cortisol were associated with faster decline in verbal fluency. Changes in cortisol measures between 2002/2004 and 2007/2009 or chronically elevated levels were not associated with cognitive performance in 2007/2009. These results, based on a large sample of community-dwelling adults suggest that variability in hypothalamic-pituitary-adrenal function is not a strong contributor to cognitive aging. |
format | Online Article Text |
id | pubmed-4099515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-40995152014-10-01 No evidence of a longitudinal association between diurnal cortisol patterns and cognition() Singh-Manoux, Archana Dugravot, Aline Elbaz, Alexis Shipley, Martin Kivimaki, Mika Kumari, Meena Neurobiol Aging Regular Article We examined the effect of salivary cortisol on cognitive performance and decline in 3229 adults (79% men), mean age 61 years. Six saliva samples over the day along with a cognition test battery were administered twice in 5 years. In fully-adjusted cross-sectional analyses from 2002 to 2004, higher waking cortisol was associated with higher reasoning score (β = 0.08, 95% confidence interval: 0.01, 0.15) but this finding was not replicated using data from 2007 to 2009. Over the mean 5 years follow-up there was decline in all cognitive tests but this decline did not vary as a function of cortisol levels; the exception was among APOE e4 carriers where a flatter diurnal slope and higher bedtime cortisol were associated with faster decline in verbal fluency. Changes in cortisol measures between 2002/2004 and 2007/2009 or chronically elevated levels were not associated with cognitive performance in 2007/2009. These results, based on a large sample of community-dwelling adults suggest that variability in hypothalamic-pituitary-adrenal function is not a strong contributor to cognitive aging. Elsevier 2014-10 /pmc/articles/PMC4099515/ /pubmed/24735831 http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.015 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Regular Article Singh-Manoux, Archana Dugravot, Aline Elbaz, Alexis Shipley, Martin Kivimaki, Mika Kumari, Meena No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title | No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title_full | No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title_fullStr | No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title_full_unstemmed | No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title_short | No evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
title_sort | no evidence of a longitudinal association between diurnal cortisol patterns and cognition() |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099515/ https://www.ncbi.nlm.nih.gov/pubmed/24735831 http://dx.doi.org/10.1016/j.neurobiolaging.2014.03.015 |
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