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Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules
We compared the survival rates and late effects for two groups of cervical cancer patients treated with almost the same external radiotherapy but different remote afterloading systems (RALS) for high-dose-rate intracavitary radiation therapy regimens. A total of 218 patients with carcinoma of the ut...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099986/ https://www.ncbi.nlm.nih.gov/pubmed/24563532 http://dx.doi.org/10.1093/jrr/rrt226 |
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author | Chatani, Masashi Tsuboi, Kazuki Yagi, Masayuki Fujiwara, Kanta Tachimoto, Rika |
author_facet | Chatani, Masashi Tsuboi, Kazuki Yagi, Masayuki Fujiwara, Kanta Tachimoto, Rika |
author_sort | Chatani, Masashi |
collection | PubMed |
description | We compared the survival rates and late effects for two groups of cervical cancer patients treated with almost the same external radiotherapy but different remote afterloading systems (RALS) for high-dose-rate intracavitary radiation therapy regimens. A total of 218 patients with carcinoma of the uterine cervix were treated. For 98 patients, intracavitary brachytherapy was delivered with 6–7.5 Gy/fraction to Point A (Group A), and for 120, 5 Gy/fraction with a modified source step size (Group B). The 3-year cause-specific survival rates by stage and treatment schedule were Group A: 91% and Group B: 96% in Stage I, 89% and 92% in Stage II, 64% and 75% in Stage III, 44% and 69% in Stage IV. The survival curves did not reveal any statistically significant differences at any stage. The 3-year cumulative local failure rates were 14% in Group A and 7% in Group B (P = 0.1202), while the actuarial rates of developing rectal complication (Grade 2 or more) at 3 years were 25% in Group A and 4% in Group B (P < 0.0001). This retrospective analysis suggests that a low dose per fraction with modified source step size is advantageous because of yielding almost the same local control but with fewer rectal complications. |
format | Online Article Text |
id | pubmed-4099986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40999862014-08-12 Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules Chatani, Masashi Tsuboi, Kazuki Yagi, Masayuki Fujiwara, Kanta Tachimoto, Rika J Radiat Res Oncology We compared the survival rates and late effects for two groups of cervical cancer patients treated with almost the same external radiotherapy but different remote afterloading systems (RALS) for high-dose-rate intracavitary radiation therapy regimens. A total of 218 patients with carcinoma of the uterine cervix were treated. For 98 patients, intracavitary brachytherapy was delivered with 6–7.5 Gy/fraction to Point A (Group A), and for 120, 5 Gy/fraction with a modified source step size (Group B). The 3-year cause-specific survival rates by stage and treatment schedule were Group A: 91% and Group B: 96% in Stage I, 89% and 92% in Stage II, 64% and 75% in Stage III, 44% and 69% in Stage IV. The survival curves did not reveal any statistically significant differences at any stage. The 3-year cumulative local failure rates were 14% in Group A and 7% in Group B (P = 0.1202), while the actuarial rates of developing rectal complication (Grade 2 or more) at 3 years were 25% in Group A and 4% in Group B (P < 0.0001). This retrospective analysis suggests that a low dose per fraction with modified source step size is advantageous because of yielding almost the same local control but with fewer rectal complications. Oxford University Press 2014-07 2014-02-20 /pmc/articles/PMC4099986/ /pubmed/24563532 http://dx.doi.org/10.1093/jrr/rrt226 Text en © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Oncology Chatani, Masashi Tsuboi, Kazuki Yagi, Masayuki Fujiwara, Kanta Tachimoto, Rika Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title | Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title_full | Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title_fullStr | Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title_full_unstemmed | Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title_short | Radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
title_sort | radiation therapy for carcinoma of the uterine cervix: comparison of two brachytherapy schedules |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099986/ https://www.ncbi.nlm.nih.gov/pubmed/24563532 http://dx.doi.org/10.1093/jrr/rrt226 |
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