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Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities

We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell...

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Autores principales: Aoki-Nakano, Mizuho, Furusawa, Yoshiya, Uzawa, Akiko, Matsumoto, Yoshitaka, Hirayama, Ryoichi, Tsuruoka, Chizuru, Ogino, Takashi, Nishio, Teiji, Kagawa, Kazufumi, Murakami, Masao, Kagiya, Go, Kume, Kyo, Hatashita, Masanori, Fukuda, Shigekazu, Yamamoto, Kazutaka, Fuji, Hiroshi, Murayama, Shigeyuki, Hata, Masaharu, Sakae, Takeji, Matsumoto, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099996/
https://www.ncbi.nlm.nih.gov/pubmed/24699001
http://dx.doi.org/10.1093/jrr/rru003
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author Aoki-Nakano, Mizuho
Furusawa, Yoshiya
Uzawa, Akiko
Matsumoto, Yoshitaka
Hirayama, Ryoichi
Tsuruoka, Chizuru
Ogino, Takashi
Nishio, Teiji
Kagawa, Kazufumi
Murakami, Masao
Kagiya, Go
Kume, Kyo
Hatashita, Masanori
Fukuda, Shigekazu
Yamamoto, Kazutaka
Fuji, Hiroshi
Murayama, Shigeyuki
Hata, Masaharu
Sakae, Takeji
Matsumoto, Hideki
author_facet Aoki-Nakano, Mizuho
Furusawa, Yoshiya
Uzawa, Akiko
Matsumoto, Yoshitaka
Hirayama, Ryoichi
Tsuruoka, Chizuru
Ogino, Takashi
Nishio, Teiji
Kagawa, Kazufumi
Murakami, Masao
Kagiya, Go
Kume, Kyo
Hatashita, Masanori
Fukuda, Shigekazu
Yamamoto, Kazutaka
Fuji, Hiroshi
Murayama, Shigeyuki
Hata, Masaharu
Sakae, Takeji
Matsumoto, Hideki
author_sort Aoki-Nakano, Mizuho
collection PubMed
description We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D(10)) in biological effectiveness. The averaged value of D(10) for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE(10) (RBE at the D(10) level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%.
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spelling pubmed-40999962014-08-12 Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities Aoki-Nakano, Mizuho Furusawa, Yoshiya Uzawa, Akiko Matsumoto, Yoshitaka Hirayama, Ryoichi Tsuruoka, Chizuru Ogino, Takashi Nishio, Teiji Kagawa, Kazufumi Murakami, Masao Kagiya, Go Kume, Kyo Hatashita, Masanori Fukuda, Shigekazu Yamamoto, Kazutaka Fuji, Hiroshi Murayama, Shigeyuki Hata, Masaharu Sakae, Takeji Matsumoto, Hideki J Radiat Res Technology We investigated the relative biological effectiveness (RBE) of therapeutic proton beams at six proton facilities in Japan with respect to cell lethality of HSG cells. The RBE of treatments could be determined from experimental data. For this purpose, we used a cell survival assay to compare the cell-killing efficiency of proton beams. Among the five linear accelerator (LINAC) X-ray machines at 4 or 6 MeV that were used as reference beams, there was only a small variation (coefficient of variation CV = 3.1% at D(10)) in biological effectiveness. The averaged value of D(10) for the proton beams at the middle position of the spread-out Bragg peak (SOBP) was 4.98. These values showed good agreement, with a CV of 4.3% among the facilities. Thus, the average RBE(10) (RBE at the D(10) level) at the middle position of the SOBP beam for six facilities in Japan was 1.05 with a CV of 2.8%. Oxford University Press 2014-07 2014-04-03 /pmc/articles/PMC4099996/ /pubmed/24699001 http://dx.doi.org/10.1093/jrr/rru003 Text en © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Technology
Aoki-Nakano, Mizuho
Furusawa, Yoshiya
Uzawa, Akiko
Matsumoto, Yoshitaka
Hirayama, Ryoichi
Tsuruoka, Chizuru
Ogino, Takashi
Nishio, Teiji
Kagawa, Kazufumi
Murakami, Masao
Kagiya, Go
Kume, Kyo
Hatashita, Masanori
Fukuda, Shigekazu
Yamamoto, Kazutaka
Fuji, Hiroshi
Murayama, Shigeyuki
Hata, Masaharu
Sakae, Takeji
Matsumoto, Hideki
Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title_full Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title_fullStr Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title_full_unstemmed Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title_short Relative biological effectiveness of therapeutic proton beams for HSG cells at Japanese proton therapy facilities
title_sort relative biological effectiveness of therapeutic proton beams for hsg cells at japanese proton therapy facilities
topic Technology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4099996/
https://www.ncbi.nlm.nih.gov/pubmed/24699001
http://dx.doi.org/10.1093/jrr/rru003
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