Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination

Ionizing radiation induces DNA double-strand breaks (DSBs). Mammalian cells repair DSBs through multiple pathways, and the repair pathway that is utilized may affect cellular radiation sensitivity. In this study, we examined effects on cellular radiosensitivity resulting from functional alterations...

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Detalles Bibliográficos
Autores principales: Ohara, Maki, Funyu, Yumi, Ebara, Shunsuke, Sakamoto, Yuki, Seki, Ryota, Iijima, Kenta, Ohishi, Akiko, Kobayashi, Junya, Komatsu, Kenshi, Tachibana, Akira, Tauchi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100003/
https://www.ncbi.nlm.nih.gov/pubmed/24614819
http://dx.doi.org/10.1093/jrr/rru011

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