Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis

Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determ...

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Autores principales: Kuo, Chao-Ying, Juan, Yung-Shun, Lu, Mei-Chin, Chiang, Michael Yen-Nan, Dai, Chang-Feng, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100144/
https://www.ncbi.nlm.nih.gov/pubmed/24914763
http://dx.doi.org/10.3390/ijms150610136
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author Kuo, Chao-Ying
Juan, Yung-Shun
Lu, Mei-Chin
Chiang, Michael Yen-Nan
Dai, Chang-Feng
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Kuo, Chao-Ying
Juan, Yung-Shun
Lu, Mei-Chin
Chiang, Michael Yen-Nan
Dai, Chang-Feng
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Kuo, Chao-Ying
collection PubMed
description Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells.
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spelling pubmed-41001442014-07-16 Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis Kuo, Chao-Ying Juan, Yung-Shun Lu, Mei-Chin Chiang, Michael Yen-Nan Dai, Chang-Feng Wu, Yang-Chang Sung, Ping-Jyun Int J Mol Sci Article Three pregnane-type steroids, including a new metabolite, 3β-methoxy-5,20-pregnadiene (1) along with two known analogues, 3β-acetoxy-5,20-pregnadiene (2) and 5α-pregna-1,20-dien-3-one (3) were isolated from the soft coral Scleronephthya flexilis. Standard spectroscopic techniques were used to determine the structure of new steroid 1. The absolute stereochemistry of steroid 2 was confirmed by X-ray diffraction analysis. Steroid 3 exhibited potent activity against MOLT-4 tumor cells. MDPI 2014-06-06 /pmc/articles/PMC4100144/ /pubmed/24914763 http://dx.doi.org/10.3390/ijms150610136 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kuo, Chao-Ying
Juan, Yung-Shun
Lu, Mei-Chin
Chiang, Michael Yen-Nan
Dai, Chang-Feng
Wu, Yang-Chang
Sung, Ping-Jyun
Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title_full Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title_fullStr Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title_full_unstemmed Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title_short Pregnane-Type Steroids from the Formosan Soft Coral Scleronephthya flexilis
title_sort pregnane-type steroids from the formosan soft coral scleronephthya flexilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100144/
https://www.ncbi.nlm.nih.gov/pubmed/24914763
http://dx.doi.org/10.3390/ijms150610136
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