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Mass Spectrometry Methodology in Lipid Analysis
Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100164/ https://www.ncbi.nlm.nih.gov/pubmed/24921707 http://dx.doi.org/10.3390/ijms150610492 |
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author | Li, Lin Han, Juanjuan Wang, Zhenpeng Liu, Jian’an Wei, Jinchao Xiong, Shaoxiang Zhao, Zhenwen |
author_facet | Li, Lin Han, Juanjuan Wang, Zhenpeng Liu, Jian’an Wei, Jinchao Xiong, Shaoxiang Zhao, Zhenwen |
author_sort | Li, Lin |
collection | PubMed |
description | Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease. |
format | Online Article Text |
id | pubmed-4100164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-41001642014-07-16 Mass Spectrometry Methodology in Lipid Analysis Li, Lin Han, Juanjuan Wang, Zhenpeng Liu, Jian’an Wei, Jinchao Xiong, Shaoxiang Zhao, Zhenwen Int J Mol Sci Review Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease. MDPI 2014-06-11 /pmc/articles/PMC4100164/ /pubmed/24921707 http://dx.doi.org/10.3390/ijms150610492 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Li, Lin Han, Juanjuan Wang, Zhenpeng Liu, Jian’an Wei, Jinchao Xiong, Shaoxiang Zhao, Zhenwen Mass Spectrometry Methodology in Lipid Analysis |
title | Mass Spectrometry Methodology in Lipid Analysis |
title_full | Mass Spectrometry Methodology in Lipid Analysis |
title_fullStr | Mass Spectrometry Methodology in Lipid Analysis |
title_full_unstemmed | Mass Spectrometry Methodology in Lipid Analysis |
title_short | Mass Spectrometry Methodology in Lipid Analysis |
title_sort | mass spectrometry methodology in lipid analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100164/ https://www.ncbi.nlm.nih.gov/pubmed/24921707 http://dx.doi.org/10.3390/ijms150610492 |
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