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Mass Spectrometry Methodology in Lipid Analysis

Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of...

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Detalles Bibliográficos
Autores principales: Li, Lin, Han, Juanjuan, Wang, Zhenpeng, Liu, Jian’an, Wei, Jinchao, Xiong, Shaoxiang, Zhao, Zhenwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100164/
https://www.ncbi.nlm.nih.gov/pubmed/24921707
http://dx.doi.org/10.3390/ijms150610492
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author Li, Lin
Han, Juanjuan
Wang, Zhenpeng
Liu, Jian’an
Wei, Jinchao
Xiong, Shaoxiang
Zhao, Zhenwen
author_facet Li, Lin
Han, Juanjuan
Wang, Zhenpeng
Liu, Jian’an
Wei, Jinchao
Xiong, Shaoxiang
Zhao, Zhenwen
author_sort Li, Lin
collection PubMed
description Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease.
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spelling pubmed-41001642014-07-16 Mass Spectrometry Methodology in Lipid Analysis Li, Lin Han, Juanjuan Wang, Zhenpeng Liu, Jian’an Wei, Jinchao Xiong, Shaoxiang Zhao, Zhenwen Int J Mol Sci Review Lipidomics is an emerging field, where the structures, functions and dynamic changes of lipids in cells, tissues or body fluids are investigated. Due to the vital roles of lipids in human physiological and pathological processes, lipidomics is attracting more and more attentions. However, because of the diversity and complexity of lipids, lipid analysis is still full of challenges. The recent development of methods for lipid extraction and analysis and the combination with bioinformatics technology greatly push forward the study of lipidomics. Among them, mass spectrometry (MS) is the most important technology for lipid analysis. In this review, the methodology based on MS for lipid analysis was introduced. It is believed that along with the rapid development of MS and its further applications to lipid analysis, more functional lipids will be identified as biomarkers and therapeutic targets and for the study of the mechanisms of disease. MDPI 2014-06-11 /pmc/articles/PMC4100164/ /pubmed/24921707 http://dx.doi.org/10.3390/ijms150610492 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Li, Lin
Han, Juanjuan
Wang, Zhenpeng
Liu, Jian’an
Wei, Jinchao
Xiong, Shaoxiang
Zhao, Zhenwen
Mass Spectrometry Methodology in Lipid Analysis
title Mass Spectrometry Methodology in Lipid Analysis
title_full Mass Spectrometry Methodology in Lipid Analysis
title_fullStr Mass Spectrometry Methodology in Lipid Analysis
title_full_unstemmed Mass Spectrometry Methodology in Lipid Analysis
title_short Mass Spectrometry Methodology in Lipid Analysis
title_sort mass spectrometry methodology in lipid analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100164/
https://www.ncbi.nlm.nih.gov/pubmed/24921707
http://dx.doi.org/10.3390/ijms150610492
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