Activation of mGluR5 Attenuates NMDA-Induced Neurotoxicity through Disruption of the NMDAR-PSD-95 Complex and Preservation of Mitochondrial Function in Differentiated PC12 Cells

Glutamate-mediated toxicity is implicated in various neuropathologic conditions, and activation of ionotropic and metabotropic glutamate receptors is considered to be the most important mechanism. It has been reported that pharmacological saturation of metabotropic glutamate receptors (mGluRs) can f...

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Detalles Bibliográficos
Autores principales: Dai, Shu-Hui, Qin, Na, Chen, Tao, Luo, Peng, Zhang, Lei, Rao, Wei, Yang, Yue-Fan, Jiang, Xiao-Fan, Fei, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100187/
https://www.ncbi.nlm.nih.gov/pubmed/24941251
http://dx.doi.org/10.3390/ijms150610892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100187/
https://www.ncbi.nlm.nih.gov/pubmed/24941251
http://dx.doi.org/10.3390/ijms150610892

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