The Constituents of Michelia compressa var. formosana and Their Bioactivities

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result s...

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Detalles Bibliográficos
Autores principales: Chan, Yu-Yi, Juang, Shin-Hun, Huang, Guan-Jhong, Liao, Yu-Ren, Chen, Yu-Fon, Wu, Chia-Che, Chang, Hui-Ting, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100189/
https://www.ncbi.nlm.nih.gov/pubmed/24941253
http://dx.doi.org/10.3390/ijms150610926
Descripción
Sumario:Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC(50) values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC(50) values in the range of 15.7–3.68 μM.

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