The Constituents of Michelia compressa var. formosana and Their Bioactivities

Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result s...

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Autores principales: Chan, Yu-Yi, Juang, Shin-Hun, Huang, Guan-Jhong, Liao, Yu-Ren, Chen, Yu-Fon, Wu, Chia-Che, Chang, Hui-Ting, Wu, Tian-Shung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100189/
https://www.ncbi.nlm.nih.gov/pubmed/24941253
http://dx.doi.org/10.3390/ijms150610926
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author Chan, Yu-Yi
Juang, Shin-Hun
Huang, Guan-Jhong
Liao, Yu-Ren
Chen, Yu-Fon
Wu, Chia-Che
Chang, Hui-Ting
Wu, Tian-Shung
author_facet Chan, Yu-Yi
Juang, Shin-Hun
Huang, Guan-Jhong
Liao, Yu-Ren
Chen, Yu-Fon
Wu, Chia-Che
Chang, Hui-Ting
Wu, Tian-Shung
author_sort Chan, Yu-Yi
collection PubMed
description Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC(50) values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC(50) values in the range of 15.7–3.68 μM.
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spelling pubmed-41001892014-07-16 The Constituents of Michelia compressa var. formosana and Their Bioactivities Chan, Yu-Yi Juang, Shin-Hun Huang, Guan-Jhong Liao, Yu-Ren Chen, Yu-Fon Wu, Chia-Che Chang, Hui-Ting Wu, Tian-Shung Int J Mol Sci Article Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC(50) values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC(50) values in the range of 15.7–3.68 μM. MDPI 2014-06-17 /pmc/articles/PMC4100189/ /pubmed/24941253 http://dx.doi.org/10.3390/ijms150610926 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chan, Yu-Yi
Juang, Shin-Hun
Huang, Guan-Jhong
Liao, Yu-Ren
Chen, Yu-Fon
Wu, Chia-Che
Chang, Hui-Ting
Wu, Tian-Shung
The Constituents of Michelia compressa var. formosana and Their Bioactivities
title The Constituents of Michelia compressa var. formosana and Their Bioactivities
title_full The Constituents of Michelia compressa var. formosana and Their Bioactivities
title_fullStr The Constituents of Michelia compressa var. formosana and Their Bioactivities
title_full_unstemmed The Constituents of Michelia compressa var. formosana and Their Bioactivities
title_short The Constituents of Michelia compressa var. formosana and Their Bioactivities
title_sort constituents of michelia compressa var. formosana and their bioactivities
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100189/
https://www.ncbi.nlm.nih.gov/pubmed/24941253
http://dx.doi.org/10.3390/ijms150610926
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