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Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats

Although physical exercise is an effective strategy for treatment of ischemic stroke, the underlying protective mechanisms are still not well understood. It has been recently demonstrated that neural progenitor cells play a vital role in the recovery of neurological function (NF) through differentia...

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Detalles Bibliográficos
Autores principales: Zheng, Hai-Qing, Zhang, Li-Ying, Luo, Jing, Li, Li-Li, Li, Menglin, Zhang, Qingjie, Hu, Xi-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100192/
https://www.ncbi.nlm.nih.gov/pubmed/24945308
http://dx.doi.org/10.3390/ijms150610974
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author Zheng, Hai-Qing
Zhang, Li-Ying
Luo, Jing
Li, Li-Li
Li, Menglin
Zhang, Qingjie
Hu, Xi-Quan
author_facet Zheng, Hai-Qing
Zhang, Li-Ying
Luo, Jing
Li, Li-Li
Li, Menglin
Zhang, Qingjie
Hu, Xi-Quan
author_sort Zheng, Hai-Qing
collection PubMed
description Although physical exercise is an effective strategy for treatment of ischemic stroke, the underlying protective mechanisms are still not well understood. It has been recently demonstrated that neural progenitor cells play a vital role in the recovery of neurological function (NF) through differentiation into mature neurons. In the current study, we observed that physical exercise significantly reduced the infarct size and improved damaged neural functional recovery after an ischemic stroke. Furthermore, we found that the treatment not only exhibited a significant increase in the number of neural progenitor cells and neurons but also decreased the apoptotic cells in the peri-infarct region, compared to a control in the absence of exercise. Importantly, the insulin-like growth factor-1 (IGF-1)/Akt signaling pathway was dramatically activated in the peri-infarct region of rats after physical exercise training. Therefore, our findings suggest that physical exercise directly influences the NF recovery process by increasing neural progenitor cell count via activation of the IGF-1/Akt signaling pathway.
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spelling pubmed-41001922014-07-16 Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats Zheng, Hai-Qing Zhang, Li-Ying Luo, Jing Li, Li-Li Li, Menglin Zhang, Qingjie Hu, Xi-Quan Int J Mol Sci Article Although physical exercise is an effective strategy for treatment of ischemic stroke, the underlying protective mechanisms are still not well understood. It has been recently demonstrated that neural progenitor cells play a vital role in the recovery of neurological function (NF) through differentiation into mature neurons. In the current study, we observed that physical exercise significantly reduced the infarct size and improved damaged neural functional recovery after an ischemic stroke. Furthermore, we found that the treatment not only exhibited a significant increase in the number of neural progenitor cells and neurons but also decreased the apoptotic cells in the peri-infarct region, compared to a control in the absence of exercise. Importantly, the insulin-like growth factor-1 (IGF-1)/Akt signaling pathway was dramatically activated in the peri-infarct region of rats after physical exercise training. Therefore, our findings suggest that physical exercise directly influences the NF recovery process by increasing neural progenitor cell count via activation of the IGF-1/Akt signaling pathway. MDPI 2014-06-18 /pmc/articles/PMC4100192/ /pubmed/24945308 http://dx.doi.org/10.3390/ijms150610974 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Zheng, Hai-Qing
Zhang, Li-Ying
Luo, Jing
Li, Li-Li
Li, Menglin
Zhang, Qingjie
Hu, Xi-Quan
Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title_full Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title_fullStr Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title_full_unstemmed Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title_short Physical Exercise Promotes Recovery of Neurological Function after Ischemic Stroke in Rats
title_sort physical exercise promotes recovery of neurological function after ischemic stroke in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100192/
https://www.ncbi.nlm.nih.gov/pubmed/24945308
http://dx.doi.org/10.3390/ijms150610974
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