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Development of organophosphate hydrolase activity in a bacterial homolog of human cholinesterase

We applied a combination of rational design and directed evolution (DE) to Bacillus subtilis p-nitrobenzyl esterase (pNBE) with the goal of enhancing organophosphorus acid anhydride hydrolase (OPAAH) activity. DE started with a designed variant, pNBE A107H, carrying a histidine homologous with human...

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Detalles Bibliográficos
Autores principales:	Legler, Patricia M., Boisvert, Susanne M., Compton, Jaimee R., Millard, Charles B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100338/ https://www.ncbi.nlm.nih.gov/pubmed/25077141 http://dx.doi.org/10.3389/fchem.2014.00046

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