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Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer

Background. This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC). Methods and Results. One hundred seven patients were prospectively enrolled into the study betw...

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Autores principales: Wang, Chin-Chou, Tseng, Chia-Cheng, Hsiao, Chang-Chun, Chang, Huang-Chih, Chang, Li-Teh, Fang, Wen-Feng, Leu, Steve, Wang, Yi-Hsi, Tsai, Tzu-Hsien, Yang, Cheng-Ta, Chen, Chih-Hung, Yip, Hon-Kan, Ho, Chi-Kung, Lin, Meng-Chih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100353/
https://www.ncbi.nlm.nih.gov/pubmed/25061601
http://dx.doi.org/10.1155/2014/173401
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author Wang, Chin-Chou
Tseng, Chia-Cheng
Hsiao, Chang-Chun
Chang, Huang-Chih
Chang, Li-Teh
Fang, Wen-Feng
Leu, Steve
Wang, Yi-Hsi
Tsai, Tzu-Hsien
Yang, Cheng-Ta
Chen, Chih-Hung
Yip, Hon-Kan
Ho, Chi-Kung
Lin, Meng-Chih
author_facet Wang, Chin-Chou
Tseng, Chia-Cheng
Hsiao, Chang-Chun
Chang, Huang-Chih
Chang, Li-Teh
Fang, Wen-Feng
Leu, Steve
Wang, Yi-Hsi
Tsai, Tzu-Hsien
Yang, Cheng-Ta
Chen, Chih-Hung
Yip, Hon-Kan
Ho, Chi-Kung
Lin, Meng-Chih
author_sort Wang, Chin-Chou
collection PubMed
description Background. This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC). Methods and Results. One hundred seven patients were prospectively enrolled into the study between April 2011 and February 2012, and each patient received regular follow-up after enrollment. Levels of four MPs in circulation, (1) platelet-derived activated MPs (PDAc-MPs), (2) platelet-derived apoptotic MPs (PDAp-MPs), (3) endothelial-derived activated MPs (EDAc-MPs), and (4) endothelial-derived apoptotic MPs (EDAp-MPs), were measured just after the patient was enrolled into the study using flow cytometry. Patients who survived for more than one year were categorized into group 1 (n = 56) (one-year survivors) and patients who survived less than one year were categorized into group 2 (n = 51) (one-year nonsurvivors). Male gender, incidence of liver metastasis, progression of disease after first-line treatment, poor performance status, and the Charlson comorbidity index were significantly higher in group 2 than in group 1 (all P < 0.05). Additionally, as measured by flow cytometry, only the circulating level of EDAc-MPs was found to be significantly higher in group 2 than in group 1 (P = 0.006). Multivariate analysis demonstrated that circulating level of EDAc-MPs along with brain metastasis and male gender significantly and independently predictive of one-year mortality (all P < 0.035). Conclusion. Circulating EDAc-MPs may be a useful biomarker predictive of one-year morality in ES-NSCLC patients.
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spelling pubmed-41003532014-07-24 Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer Wang, Chin-Chou Tseng, Chia-Cheng Hsiao, Chang-Chun Chang, Huang-Chih Chang, Li-Teh Fang, Wen-Feng Leu, Steve Wang, Yi-Hsi Tsai, Tzu-Hsien Yang, Cheng-Ta Chen, Chih-Hung Yip, Hon-Kan Ho, Chi-Kung Lin, Meng-Chih Biomed Res Int Research Article Background. This study tested the hypothesis that circulating microparticles (MPs) are useful biomarkers for predicting one-year mortality in patients with end-stage non-small cell lung cancer (ES-NSCLC). Methods and Results. One hundred seven patients were prospectively enrolled into the study between April 2011 and February 2012, and each patient received regular follow-up after enrollment. Levels of four MPs in circulation, (1) platelet-derived activated MPs (PDAc-MPs), (2) platelet-derived apoptotic MPs (PDAp-MPs), (3) endothelial-derived activated MPs (EDAc-MPs), and (4) endothelial-derived apoptotic MPs (EDAp-MPs), were measured just after the patient was enrolled into the study using flow cytometry. Patients who survived for more than one year were categorized into group 1 (n = 56) (one-year survivors) and patients who survived less than one year were categorized into group 2 (n = 51) (one-year nonsurvivors). Male gender, incidence of liver metastasis, progression of disease after first-line treatment, poor performance status, and the Charlson comorbidity index were significantly higher in group 2 than in group 1 (all P < 0.05). Additionally, as measured by flow cytometry, only the circulating level of EDAc-MPs was found to be significantly higher in group 2 than in group 1 (P = 0.006). Multivariate analysis demonstrated that circulating level of EDAc-MPs along with brain metastasis and male gender significantly and independently predictive of one-year mortality (all P < 0.035). Conclusion. Circulating EDAc-MPs may be a useful biomarker predictive of one-year morality in ES-NSCLC patients. Hindawi Publishing Corporation 2014 2014-06-29 /pmc/articles/PMC4100353/ /pubmed/25061601 http://dx.doi.org/10.1155/2014/173401 Text en Copyright © 2014 Chin-Chou Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Chin-Chou
Tseng, Chia-Cheng
Hsiao, Chang-Chun
Chang, Huang-Chih
Chang, Li-Teh
Fang, Wen-Feng
Leu, Steve
Wang, Yi-Hsi
Tsai, Tzu-Hsien
Yang, Cheng-Ta
Chen, Chih-Hung
Yip, Hon-Kan
Ho, Chi-Kung
Lin, Meng-Chih
Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title_full Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title_fullStr Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title_full_unstemmed Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title_short Circulating Endothelial-Derived Activated Microparticle: A Useful Biomarker for Predicting One-Year Mortality in Patients with Advanced Non-Small Cell Lung Cancer
title_sort circulating endothelial-derived activated microparticle: a useful biomarker for predicting one-year mortality in patients with advanced non-small cell lung cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100353/
https://www.ncbi.nlm.nih.gov/pubmed/25061601
http://dx.doi.org/10.1155/2014/173401
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