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Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice

Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14...

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Detalles Bibliográficos
Autores principales: Yang, Hang, Qi, Haili, Ren, Jingli, Cui, Jing, Li, Zhenfeng, Waldum, Helge L., Cui, Guanglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100381/
https://www.ncbi.nlm.nih.gov/pubmed/25093140
http://dx.doi.org/10.1155/2014/130981
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author Yang, Hang
Qi, Haili
Ren, Jingli
Cui, Jing
Li, Zhenfeng
Waldum, Helge L.
Cui, Guanglin
author_facet Yang, Hang
Qi, Haili
Ren, Jingli
Cui, Jing
Li, Zhenfeng
Waldum, Helge L.
Cui, Guanglin
author_sort Yang, Hang
collection PubMed
description Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes.
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spelling pubmed-41003812014-08-04 Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice Yang, Hang Qi, Haili Ren, Jingli Cui, Jing Li, Zhenfeng Waldum, Helge L. Cui, Guanglin Int J Inflam Research Article Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes. Hindawi Publishing Corporation 2014 2014-06-29 /pmc/articles/PMC4100381/ /pubmed/25093140 http://dx.doi.org/10.1155/2014/130981 Text en Copyright © 2014 Hang Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Hang
Qi, Haili
Ren, Jingli
Cui, Jing
Li, Zhenfeng
Waldum, Helge L.
Cui, Guanglin
Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title_full Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title_fullStr Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title_full_unstemmed Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title_short Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
title_sort involvement of nf-κb/il-6 pathway in the processing of colorectal carcinogenesis in colitis mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100381/
https://www.ncbi.nlm.nih.gov/pubmed/25093140
http://dx.doi.org/10.1155/2014/130981
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