Cargando…
Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100381/ https://www.ncbi.nlm.nih.gov/pubmed/25093140 http://dx.doi.org/10.1155/2014/130981 |
_version_ | 1782326664758296576 |
---|---|
author | Yang, Hang Qi, Haili Ren, Jingli Cui, Jing Li, Zhenfeng Waldum, Helge L. Cui, Guanglin |
author_facet | Yang, Hang Qi, Haili Ren, Jingli Cui, Jing Li, Zhenfeng Waldum, Helge L. Cui, Guanglin |
author_sort | Yang, Hang |
collection | PubMed |
description | Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes. |
format | Online Article Text |
id | pubmed-4100381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41003812014-08-04 Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice Yang, Hang Qi, Haili Ren, Jingli Cui, Jing Li, Zhenfeng Waldum, Helge L. Cui, Guanglin Int J Inflam Research Article Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes. Hindawi Publishing Corporation 2014 2014-06-29 /pmc/articles/PMC4100381/ /pubmed/25093140 http://dx.doi.org/10.1155/2014/130981 Text en Copyright © 2014 Hang Yang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Yang, Hang Qi, Haili Ren, Jingli Cui, Jing Li, Zhenfeng Waldum, Helge L. Cui, Guanglin Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title_full | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title_fullStr | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title_full_unstemmed | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title_short | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
title_sort | involvement of nf-κb/il-6 pathway in the processing of colorectal carcinogenesis in colitis mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100381/ https://www.ncbi.nlm.nih.gov/pubmed/25093140 http://dx.doi.org/10.1155/2014/130981 |
work_keys_str_mv | AT yanghang involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT qihaili involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT renjingli involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT cuijing involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT lizhenfeng involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT waldumhelgel involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice AT cuiguanglin involvementofnfkbil6pathwayintheprocessingofcolorectalcarcinogenesisincolitismice |