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ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU

BACKGROUND: Prognostic abilities of medical parameters, which are scoring systems, measurements and biomarkers, are important for stratifying critically ill patients. Indocyanine green plasma disappearance (ICG-PDR) is an established clinical tool for the assessment of liver perfusion and function....

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Autores principales: Zoller, Bernhard, Spanaus, Katharina, Gerster, Rahel, Fasshauer, Mario, Stehberger, Paul A, Klinzing, Stephanie, Vergopoulos, Athanasios, von Eckardstein, Arnold, Béchir, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100565/
https://www.ncbi.nlm.nih.gov/pubmed/25045579
http://dx.doi.org/10.1186/s13613-014-0019-7
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author Zoller, Bernhard
Spanaus, Katharina
Gerster, Rahel
Fasshauer, Mario
Stehberger, Paul A
Klinzing, Stephanie
Vergopoulos, Athanasios
von Eckardstein, Arnold
Béchir, Markus
author_facet Zoller, Bernhard
Spanaus, Katharina
Gerster, Rahel
Fasshauer, Mario
Stehberger, Paul A
Klinzing, Stephanie
Vergopoulos, Athanasios
von Eckardstein, Arnold
Béchir, Markus
author_sort Zoller, Bernhard
collection PubMed
description BACKGROUND: Prognostic abilities of medical parameters, which are scoring systems, measurements and biomarkers, are important for stratifying critically ill patients. Indocyanine green plasma disappearance (ICG-PDR) is an established clinical tool for the assessment of liver perfusion and function. Copeptin, MR-proANP and pro-ADM are biomarkers whose prognostic value is still unclear. The goal of this prospective study was to evaluate ICG-PDR, copeptin, MR-proANP and pro-ADM to predict prolonged length of stay (pLOS) in the ICU. METHODS: This study was conducted as a prospective single center study including 110 consecutively admitted ICU patients. Primary endpoint was prolonged length of stay (pLOS) in the ICU, defined as more than three days of stay there. RESULTS: ROC analysis showed an AUC of 0.73 for ICG-PDR, 0.70 for SAPS II, 0.65 for MR-proANP, 0.64 for pro-ADM and 0.54 for copeptin for pLOS in the ICU. CONCLUSIONS: The prediction of pLOS in the ICU might be better by means of ICG-PDR than with the new biomarkers copeptin, MR-proANP or pro-ADM. Nevertheless, there is more need for research to evaluate whether ICG-PDR is an overall prognostic marker for pLOS. TRIAL REGISTRATION: (ClinicalTrials.gov number, NCT01126554).
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spelling pubmed-41005652014-07-18 ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU Zoller, Bernhard Spanaus, Katharina Gerster, Rahel Fasshauer, Mario Stehberger, Paul A Klinzing, Stephanie Vergopoulos, Athanasios von Eckardstein, Arnold Béchir, Markus Ann Intensive Care Research BACKGROUND: Prognostic abilities of medical parameters, which are scoring systems, measurements and biomarkers, are important for stratifying critically ill patients. Indocyanine green plasma disappearance (ICG-PDR) is an established clinical tool for the assessment of liver perfusion and function. Copeptin, MR-proANP and pro-ADM are biomarkers whose prognostic value is still unclear. The goal of this prospective study was to evaluate ICG-PDR, copeptin, MR-proANP and pro-ADM to predict prolonged length of stay (pLOS) in the ICU. METHODS: This study was conducted as a prospective single center study including 110 consecutively admitted ICU patients. Primary endpoint was prolonged length of stay (pLOS) in the ICU, defined as more than three days of stay there. RESULTS: ROC analysis showed an AUC of 0.73 for ICG-PDR, 0.70 for SAPS II, 0.65 for MR-proANP, 0.64 for pro-ADM and 0.54 for copeptin for pLOS in the ICU. CONCLUSIONS: The prediction of pLOS in the ICU might be better by means of ICG-PDR than with the new biomarkers copeptin, MR-proANP or pro-ADM. Nevertheless, there is more need for research to evaluate whether ICG-PDR is an overall prognostic marker for pLOS. TRIAL REGISTRATION: (ClinicalTrials.gov number, NCT01126554). Springer 2014-07-08 /pmc/articles/PMC4100565/ /pubmed/25045579 http://dx.doi.org/10.1186/s13613-014-0019-7 Text en Copyright © 2014 Zoller et al.; licensee Springer http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Zoller, Bernhard
Spanaus, Katharina
Gerster, Rahel
Fasshauer, Mario
Stehberger, Paul A
Klinzing, Stephanie
Vergopoulos, Athanasios
von Eckardstein, Arnold
Béchir, Markus
ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title_full ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title_fullStr ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title_full_unstemmed ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title_short ICG-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the ICU
title_sort icg-liver test versus new biomarkers as prognostic markers for prolonged length of stay in critically ill patients - a prospective study of accuracy for prediction of length of stay in the icu
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100565/
https://www.ncbi.nlm.nih.gov/pubmed/25045579
http://dx.doi.org/10.1186/s13613-014-0019-7
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