Evaluation of [(11)C]oseltamivir uptake into the brain during immune activation by systemic polyinosine-polycytidylic acid injection: a quantitative PET study using juvenile monkey models of viral infection

BACKGROUND: Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs). Immune response to viral infection is suspected to cause elevation of drug con...

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Detalles Bibliográficos
Autores principales: Seki, Chie, Oh-Nishi, Arata, Nagai, Yuji, Minamimoto, Takafumi, Obayashi, Shigeru, Higuchi, Makoto, Takei, Makoto, Furutsuka, Kenji, Ito, Takehito, Zhang, Ming-Rong, Ito, Hiroshi, Ito, Mototsugu, Ito, Sumito, Kusuhara, Hiroyuki, Sugiyama, Yuichi, Suhara, Tetsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100568/
https://www.ncbi.nlm.nih.gov/pubmed/25045603
http://dx.doi.org/10.1186/s13550-014-0024-8

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