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Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi
The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, wh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100779/ https://www.ncbi.nlm.nih.gov/pubmed/19745516 |
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author | Santander, Javier M Roland, Kenneth L. Curtiss, Roy |
author_facet | Santander, Javier M Roland, Kenneth L. Curtiss, Roy |
author_sort | Santander, Javier M |
collection | PubMed |
description | The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development. |
format | Online Article Text |
id | pubmed-4100779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
record_format | MEDLINE/PubMed |
spelling | pubmed-41007792014-07-16 Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi Santander, Javier M Roland, Kenneth L. Curtiss, Roy J Infect Dev Ctries Article The synthesis of Vi polysaccharide, a major virulence determinant in Salmonella enterica serotype Typhi (S. Typhi), is under the control of two regulatory systems, ompR-envZ and rscB-rscC, which respond to changes in osmolarity. Some S. Typhi isolates exhibit over-expression of Vi polysaccharide, which masks clinical detection of LPS O-antigen. This variation in Vi polysaccharide and O-antigen display (VW variation) has been observed since the initial studies of S. Typhi. We have reported that the status of the rpoS gene is responsible for this phenomenon. We review the regulatory network of the Vi polysaccharide, linking osmolarity and RpoS expression. Also, we discuss how this may impact live attenuated Salmonella vaccine development. 2008-12-01 /pmc/articles/PMC4100779/ /pubmed/19745516 Text en Copyright © 2008 Santander et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Santander, Javier M Roland, Kenneth L. Curtiss, Roy Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title_full | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title_fullStr | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title_full_unstemmed | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title_short | Regulation of Vi Capsular Polysaccharide Synthesis in Salmonella enterica Serotype Typhi |
title_sort | regulation of vi capsular polysaccharide synthesis in salmonella enterica serotype typhi |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100779/ https://www.ncbi.nlm.nih.gov/pubmed/19745516 |
work_keys_str_mv | AT santanderjavierm regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi AT rolandkennethl regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi AT curtissroy regulationofvicapsularpolysaccharidesynthesisinsalmonellaentericaserotypetyphi |