Novel Human Butyrylcholinesterase Variants: Toward Organophosphonate Detoxication

[Image: see text] Human butyrylcholinesterase (hBChE) is currently being developed as a detoxication enzyme for stoichiometric binding and/or catalytic hydrolysis of organophosphates. Herein, we describe the use of a molecular evolution method to develop novel hBChE variants with increased resistanc...

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Detalles Bibliográficos
Autores principales: Dwyer, Mary, Javor, Sacha, Ryan, Daniel A., Smith, Emily M., Wang, Beilin, Zhang, Jun, Cashman, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100784/
https://www.ncbi.nlm.nih.gov/pubmed/24902043
http://dx.doi.org/10.1021/bi500491w

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