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Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells

Human endometrium-derived mesenchymal stem cells (hMESCs) enter the premature senescence under sublethal oxidative stress, however underlying mechanism remains unknown. Here, we showed that exogenous H(2)O(2) induces a rapid phosphorylation and co-localization of ATM, H2A.X, 53BP1 leading to DNA dam...

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Detalles Bibliográficos
Autores principales:	Borodkina, Aleksandra, Shatrova, Alla, Abushik, Polina, Nikolsky, Nikolay, Burova, Elena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100810/ https://www.ncbi.nlm.nih.gov/pubmed/24934860

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