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Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study
OBJECTIVE: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice. METHODS: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centro de Investigaciones y Publicaciones Farmaceuticas
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100947/ https://www.ncbi.nlm.nih.gov/pubmed/25035713 |
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author | Cunico, Cássia Picheth, Geraldo Correr, Cassyano J. Scartezini, Marileia |
author_facet | Cunico, Cássia Picheth, Geraldo Correr, Cassyano J. Scartezini, Marileia |
author_sort | Cunico, Cássia |
collection | PubMed |
description | OBJECTIVE: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice. METHODS: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population studied consists of patients assisted by the Public Health Service in the far-west region of the State of Santa Catarina, Brazil. The Medication Possession Ratio obtained from pharmacy refill data was used to measure patient adherence. Therapeutic effectiveness was evaluated based on the difference obtained in the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, before and after taking the drug, in an average time of 8.3 months. RESULTS: Following the treatment with hypolipidemic agents, it has been observed a reduction of 14.3% for total cholesterol, 19.6% for LDL-cholesterol, and 14.4% for triglycerides. HDL-cholesterol increased by an 8.0% average. The major changes in lipid profile were promoted by atorvastatin 20 mg daily. The medication adherence rate decreased over the monitoring period. Adherence rates below 60% were associated with therapeutic failure, while rates equal to 80% or higher were associated with the best response to the lipid-lowering drugs. CONCLUSION: Adherence to hypolipidemic agents is higher at the beginning of the treatment, but it decreases over time, affecting the achievement of therapeutic goals. |
format | Online Article Text |
id | pubmed-4100947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Centro de Investigaciones y Publicaciones Farmaceuticas |
record_format | MEDLINE/PubMed |
spelling | pubmed-41009472014-07-17 Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study Cunico, Cássia Picheth, Geraldo Correr, Cassyano J. Scartezini, Marileia Pharm Pract (Granada) Original Research OBJECTIVE: to evaluate the relation between patient adherence and therapeutic effectiveness of hypolipidemic agents in clinical practice. METHODS: A retrospective cohort study of 417 patients using hypolipidemic drugs (simvastatin, atorvastatin) between 2003 and 2010 was performed. The population studied consists of patients assisted by the Public Health Service in the far-west region of the State of Santa Catarina, Brazil. The Medication Possession Ratio obtained from pharmacy refill data was used to measure patient adherence. Therapeutic effectiveness was evaluated based on the difference obtained in the serum levels of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, before and after taking the drug, in an average time of 8.3 months. RESULTS: Following the treatment with hypolipidemic agents, it has been observed a reduction of 14.3% for total cholesterol, 19.6% for LDL-cholesterol, and 14.4% for triglycerides. HDL-cholesterol increased by an 8.0% average. The major changes in lipid profile were promoted by atorvastatin 20 mg daily. The medication adherence rate decreased over the monitoring period. Adherence rates below 60% were associated with therapeutic failure, while rates equal to 80% or higher were associated with the best response to the lipid-lowering drugs. CONCLUSION: Adherence to hypolipidemic agents is higher at the beginning of the treatment, but it decreases over time, affecting the achievement of therapeutic goals. Centro de Investigaciones y Publicaciones Farmaceuticas 2014 2014-03-15 /pmc/articles/PMC4100947/ /pubmed/25035713 Text en Copyright: © Pharmacy Practice http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY-NC-ND 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Cunico, Cássia Picheth, Geraldo Correr, Cassyano J. Scartezini, Marileia Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents in a population of patients in Brazil: a retrospective cohort study |
title | Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in Brazil: a retrospective cohort study |
title_full | Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in Brazil: a retrospective cohort study |
title_fullStr | Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in Brazil: a retrospective cohort study |
title_full_unstemmed | Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in Brazil: a retrospective cohort study |
title_short | Assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in Brazil: a retrospective cohort study |
title_sort | assessing the adherence to and the therapeutic effectiveness of hypolipidemic agents
in a population of patients in brazil: a retrospective cohort study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100947/ https://www.ncbi.nlm.nih.gov/pubmed/25035713 |
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