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Chagas Disease: Still Many Unsolved Issues

Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease...

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Autores principales: Álvarez, José M., Fonseca, Raissa, Borges da Silva, Henrique, Marinho, Cláudio R. F., Bortoluci, Karina R., Sardinha, Luiz R., Epiphanio, Sabrina, D'Império Lima, Maria Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101227/
https://www.ncbi.nlm.nih.gov/pubmed/25104883
http://dx.doi.org/10.1155/2014/912965
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author Álvarez, José M.
Fonseca, Raissa
Borges da Silva, Henrique
Marinho, Cláudio R. F.
Bortoluci, Karina R.
Sardinha, Luiz R.
Epiphanio, Sabrina
D'Império Lima, Maria Regina
author_facet Álvarez, José M.
Fonseca, Raissa
Borges da Silva, Henrique
Marinho, Cláudio R. F.
Bortoluci, Karina R.
Sardinha, Luiz R.
Epiphanio, Sabrina
D'Império Lima, Maria Regina
author_sort Álvarez, José M.
collection PubMed
description Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology.
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spelling pubmed-41012272014-08-07 Chagas Disease: Still Many Unsolved Issues Álvarez, José M. Fonseca, Raissa Borges da Silva, Henrique Marinho, Cláudio R. F. Bortoluci, Karina R. Sardinha, Luiz R. Epiphanio, Sabrina D'Império Lima, Maria Regina Mediators Inflamm Review Article Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology. Hindawi Publishing Corporation 2014 2014-06-29 /pmc/articles/PMC4101227/ /pubmed/25104883 http://dx.doi.org/10.1155/2014/912965 Text en Copyright © 2014 José M. Álvarez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Álvarez, José M.
Fonseca, Raissa
Borges da Silva, Henrique
Marinho, Cláudio R. F.
Bortoluci, Karina R.
Sardinha, Luiz R.
Epiphanio, Sabrina
D'Império Lima, Maria Regina
Chagas Disease: Still Many Unsolved Issues
title Chagas Disease: Still Many Unsolved Issues
title_full Chagas Disease: Still Many Unsolved Issues
title_fullStr Chagas Disease: Still Many Unsolved Issues
title_full_unstemmed Chagas Disease: Still Many Unsolved Issues
title_short Chagas Disease: Still Many Unsolved Issues
title_sort chagas disease: still many unsolved issues
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101227/
https://www.ncbi.nlm.nih.gov/pubmed/25104883
http://dx.doi.org/10.1155/2014/912965
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