Prion Fragment Peptides Are Digested with Membrane Type Matrix Metalloproteinases and Acquire Enzyme Resistance through Cu(2+)-Binding

Prions are the cause of neurodegenerative disease in humans and other mammals. The structural conversion of the prion protein (PrP) from a normal cellular protein (PrP(C)) to a protease-resistant isoform (PrP(Sc)) is thought to relate to Cu(2+) binding to histidine residues. In this study, we focuse...

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Detalles Bibliográficos
Autores principales: Kojima, Aya, Konishi, Motomi, Akizawa, Toshifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101495/
https://www.ncbi.nlm.nih.gov/pubmed/24970228
http://dx.doi.org/10.3390/biom4020510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101495/
https://www.ncbi.nlm.nih.gov/pubmed/24970228
http://dx.doi.org/10.3390/biom4020510

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