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Prion Fragment Peptides Are Digested with Membrane Type Matrix Metalloproteinases and Acquire Enzyme Resistance through Cu(2+)-Binding
Prions are the cause of neurodegenerative disease in humans and other mammals. The structural conversion of the prion protein (PrP) from a normal cellular protein (PrP(C)) to a protease-resistant isoform (PrP(Sc)) is thought to relate to Cu(2+) binding to histidine residues. In this study, we focuse...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101495/ https://www.ncbi.nlm.nih.gov/pubmed/24970228 http://dx.doi.org/10.3390/biom4020510 |