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Evolutionary Implications of Metal Binding Features in Different Species’ Prion Protein: An Inorganic Point of View
Prion disorders are a group of fatal neurodegenerative conditions of mammals. The key molecular event in the pathogenesis of such diseases is the conformational conversion of prion protein, PrP(C), into a misfolded form rich in β-sheet structure, PrP(Sc), but the detailed mechanistic aspects of prio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101497/ https://www.ncbi.nlm.nih.gov/pubmed/24970230 http://dx.doi.org/10.3390/biom4020546 |