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Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease

BACKGROUND/AIMS: Gastroesophageal reflux disease is one of the most common causes of chronic cough and is a potential risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors for reflux esophagitis (RE)...

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Autores principales: Kim, Seo Woo, Lee, Jin Hwa, Sim, Yun Su, Ryu, Yon Ju, Chang, Jung Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101593/
https://www.ncbi.nlm.nih.gov/pubmed/25045294
http://dx.doi.org/10.3904/kjim.2014.29.4.466
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author Kim, Seo Woo
Lee, Jin Hwa
Sim, Yun Su
Ryu, Yon Ju
Chang, Jung Hyun
author_facet Kim, Seo Woo
Lee, Jin Hwa
Sim, Yun Su
Ryu, Yon Ju
Chang, Jung Hyun
author_sort Kim, Seo Woo
collection PubMed
description BACKGROUND/AIMS: Gastroesophageal reflux disease is one of the most common causes of chronic cough and is a potential risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors for reflux esophagitis (RE) in COPD patients. METHODS: From our hospital database, between September 2006 and April 2010, we searched for subjects who were 40 years old or older and had undergone both postbronchodilator spirometry and esophagogastroduodenoscopy (EGD). COPD was defined as having a ratio of forced expiratory volume in 1 second to forced vital capacity < 0.7 in postbronchodilator spirometry and no abnormality causing airway obstruction, except emphysematous changes, on a chest X-ray. The diagnosis of RE was based on a mucosal break surrounding the distal esophageal sphincter through EGD. RESULTS: In total, 253 patients with COPD were enrolled. The prevalence of RE in COPD was 30% (76/253). Multiple logistic regression analyses revealed that age (odds ratio [OR], 0.950; 95% confidence interval [CI], 0.918 to 0.983; p = 0.003), smoking pack-years (OR, 1.015; 95% CI, 1.004 to 1.025; p = 0.006), and inhaled anticholinergics (OR, 0.516; 95% CI, 0.271 to 0.982; p = 0.044) were independently associated with RE in COPD patients. CONCLUSIONS: The prevalence of RE in our COPD patients was higher than that reported previously in the Korean general population. In COPD, smoking increased the risk of RE, whereas inhaled anticholinergics may be associated with a reduced risk of RE.
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spelling pubmed-41015932014-07-18 Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease Kim, Seo Woo Lee, Jin Hwa Sim, Yun Su Ryu, Yon Ju Chang, Jung Hyun Korean J Intern Med Original Article BACKGROUND/AIMS: Gastroesophageal reflux disease is one of the most common causes of chronic cough and is a potential risk factor for the exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the prevalence and risk factors for reflux esophagitis (RE) in COPD patients. METHODS: From our hospital database, between September 2006 and April 2010, we searched for subjects who were 40 years old or older and had undergone both postbronchodilator spirometry and esophagogastroduodenoscopy (EGD). COPD was defined as having a ratio of forced expiratory volume in 1 second to forced vital capacity < 0.7 in postbronchodilator spirometry and no abnormality causing airway obstruction, except emphysematous changes, on a chest X-ray. The diagnosis of RE was based on a mucosal break surrounding the distal esophageal sphincter through EGD. RESULTS: In total, 253 patients with COPD were enrolled. The prevalence of RE in COPD was 30% (76/253). Multiple logistic regression analyses revealed that age (odds ratio [OR], 0.950; 95% confidence interval [CI], 0.918 to 0.983; p = 0.003), smoking pack-years (OR, 1.015; 95% CI, 1.004 to 1.025; p = 0.006), and inhaled anticholinergics (OR, 0.516; 95% CI, 0.271 to 0.982; p = 0.044) were independently associated with RE in COPD patients. CONCLUSIONS: The prevalence of RE in our COPD patients was higher than that reported previously in the Korean general population. In COPD, smoking increased the risk of RE, whereas inhaled anticholinergics may be associated with a reduced risk of RE. The Korean Association of Internal Medicine 2014-07 2014-06-27 /pmc/articles/PMC4101593/ /pubmed/25045294 http://dx.doi.org/10.3904/kjim.2014.29.4.466 Text en Copyright © 2014 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Seo Woo
Lee, Jin Hwa
Sim, Yun Su
Ryu, Yon Ju
Chang, Jung Hyun
Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title_full Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title_fullStr Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title_full_unstemmed Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title_short Prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
title_sort prevalence and risk factors for reflux esophagitis in patients with chronic obstructive pulmonary disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101593/
https://www.ncbi.nlm.nih.gov/pubmed/25045294
http://dx.doi.org/10.3904/kjim.2014.29.4.466
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