Cargando…

Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum

BACKGROUND/AIMS: Recently, many cases of vitamin K-dependent coagulopathy of unknown origin have been reported. Such patients lack any relevant family history and have no systemic disease, raising suspicion of superwarfarin intoxication. We evaluated individual risk factors causing coagulopathy and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Hee-Jeong, You, Mi-Ra, Moon, Woo-Ram, Sul, Hyoung, Chung, Choon-Hae, Park, Chi-Young, Park, Sang-Gon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Internal Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101597/
https://www.ncbi.nlm.nih.gov/pubmed/25045298
http://dx.doi.org/10.3904/kjim.2014.29.4.498
_version_ 1782480928800505856
author Lee, Hee-Jeong
You, Mi-Ra
Moon, Woo-Ram
Sul, Hyoung
Chung, Choon-Hae
Park, Chi-Young
Park, Sang-Gon
author_facet Lee, Hee-Jeong
You, Mi-Ra
Moon, Woo-Ram
Sul, Hyoung
Chung, Choon-Hae
Park, Chi-Young
Park, Sang-Gon
author_sort Lee, Hee-Jeong
collection PubMed
description BACKGROUND/AIMS: Recently, many cases of vitamin K-dependent coagulopathy of unknown origin have been reported. Such patients lack any relevant family history and have no systemic disease, raising suspicion of superwarfarin intoxication. We evaluated individual risk factors causing coagulopathy and hemorrhagic symptoms in patients with suspected superwarfarin intoxication. In addition, we determined how to effectively treat vitamin K-dependent coagulopathy caused by suspected superwarfarin intoxication. METHODS: Seven patients with suspected superwarfarin intoxication who lacked any definitive history of rodenticide ingestion were included. Thirty-one patients initially diagnosed with rodenticide poisoning were also included. We performed a retrospective chart review of all subjects and examined clinical data including patient demographics and medical histories. RESULTS: Patients initially diagnosed with rodenticide poisoning were divided into two groups, one of which had a laboratory abnormality (prothrombin time [PT] > 13 seconds) and another group with PTs in the normal range. There was no significant difference between the two groups in any of age, gender, the extent of chronic alcohol consumption, the causative rodenticide, psychiatric problems, ingestion of drugs interacting with warfarin, the extent of intoxication, or the type of ingestion attempt. The albumin level of the former group was significantly lower than that of the latter group (p = 0.014). Furthermore, a significant difference between the two groups was evident in terms of simultaneous ingestion of rodenticide and alcohol (p = 0.023). CONCLUSIONS: Most patients with superwarfarin poisoning did not exhibit any complication. When such complications were evident, they were associated with serum albumin level and coingestion of rodenticide and alcohol.
format Online
Article
Text
id pubmed-4101597
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher The Korean Association of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-41015972014-07-18 Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum Lee, Hee-Jeong You, Mi-Ra Moon, Woo-Ram Sul, Hyoung Chung, Choon-Hae Park, Chi-Young Park, Sang-Gon Korean J Intern Med Original Article BACKGROUND/AIMS: Recently, many cases of vitamin K-dependent coagulopathy of unknown origin have been reported. Such patients lack any relevant family history and have no systemic disease, raising suspicion of superwarfarin intoxication. We evaluated individual risk factors causing coagulopathy and hemorrhagic symptoms in patients with suspected superwarfarin intoxication. In addition, we determined how to effectively treat vitamin K-dependent coagulopathy caused by suspected superwarfarin intoxication. METHODS: Seven patients with suspected superwarfarin intoxication who lacked any definitive history of rodenticide ingestion were included. Thirty-one patients initially diagnosed with rodenticide poisoning were also included. We performed a retrospective chart review of all subjects and examined clinical data including patient demographics and medical histories. RESULTS: Patients initially diagnosed with rodenticide poisoning were divided into two groups, one of which had a laboratory abnormality (prothrombin time [PT] > 13 seconds) and another group with PTs in the normal range. There was no significant difference between the two groups in any of age, gender, the extent of chronic alcohol consumption, the causative rodenticide, psychiatric problems, ingestion of drugs interacting with warfarin, the extent of intoxication, or the type of ingestion attempt. The albumin level of the former group was significantly lower than that of the latter group (p = 0.014). Furthermore, a significant difference between the two groups was evident in terms of simultaneous ingestion of rodenticide and alcohol (p = 0.023). CONCLUSIONS: Most patients with superwarfarin poisoning did not exhibit any complication. When such complications were evident, they were associated with serum albumin level and coingestion of rodenticide and alcohol. The Korean Association of Internal Medicine 2014-07 2014-06-27 /pmc/articles/PMC4101597/ /pubmed/25045298 http://dx.doi.org/10.3904/kjim.2014.29.4.498 Text en Copyright © 2014 The Korean Association of Internal Medicine http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Hee-Jeong
You, Mi-Ra
Moon, Woo-Ram
Sul, Hyoung
Chung, Choon-Hae
Park, Chi-Young
Park, Sang-Gon
Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title_full Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title_fullStr Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title_full_unstemmed Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title_short Evaluation of risk factors in patients with vitamin K-dependent coagulopathy presumed to be caused by exposure to brodifacoum
title_sort evaluation of risk factors in patients with vitamin k-dependent coagulopathy presumed to be caused by exposure to brodifacoum
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101597/
https://www.ncbi.nlm.nih.gov/pubmed/25045298
http://dx.doi.org/10.3904/kjim.2014.29.4.498
work_keys_str_mv AT leeheejeong evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT youmira evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT moonwooram evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT sulhyoung evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT chungchoonhae evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT parkchiyoung evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum
AT parksanggon evaluationofriskfactorsinpatientswithvitaminkdependentcoagulopathypresumedtobecausedbyexposuretobrodifacoum