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Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO(2) concentrations caused by climate changes contribute to an increase of pollen...

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Autores principales: Kim, Mi-Ae, Yoon, Moon-Gyung, Jin, Hyun-Jung, Shin, Yoo-Seob, Park, Hae-Sim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101772/
https://www.ncbi.nlm.nih.gov/pubmed/25045240
http://dx.doi.org/10.3346/jkms.2014.29.7.1025
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author Kim, Mi-Ae
Yoon, Moon-Gyung
Jin, Hyun-Jung
Shin, Yoo-Seob
Park, Hae-Sim
author_facet Kim, Mi-Ae
Yoon, Moon-Gyung
Jin, Hyun-Jung
Shin, Yoo-Seob
Park, Hae-Sim
author_sort Kim, Mi-Ae
collection PubMed
description Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO(2) concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-41017722014-07-18 Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients Kim, Mi-Ae Yoon, Moon-Gyung Jin, Hyun-Jung Shin, Yoo-Seob Park, Hae-Sim J Korean Med Sci Brief Communication Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO(2) concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens. GRAPHICAL ABSTRACT: [Image: see text] The Korean Academy of Medical Sciences 2014-07 2014-07-11 /pmc/articles/PMC4101772/ /pubmed/25045240 http://dx.doi.org/10.3346/jkms.2014.29.7.1025 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Kim, Mi-Ae
Yoon, Moon-Gyung
Jin, Hyun-Jung
Shin, Yoo-Seob
Park, Hae-Sim
Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title_full Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title_fullStr Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title_full_unstemmed Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title_short Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
title_sort paradoxical increase of ige binding components during allergen-specific immunotherapy in pollinosis patients
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101772/
https://www.ncbi.nlm.nih.gov/pubmed/25045240
http://dx.doi.org/10.3346/jkms.2014.29.7.1025
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