Cargando…
Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis
The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Academy of Medical Sciences
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101783/ https://www.ncbi.nlm.nih.gov/pubmed/25045227 http://dx.doi.org/10.3346/jkms.2014.29.7.950 |
_version_ | 1782480955860058112 |
---|---|
author | Choi, Yun Ha Hong, Young Joon Ahn, Youngkeun Park, In Hyae Jeong, Myung Ho |
author_facet | Choi, Yun Ha Hong, Young Joon Ahn, Youngkeun Park, In Hyae Jeong, Myung Ho |
author_sort | Choi, Yun Ha |
collection | PubMed |
description | The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR≤2.73 [n=370]) vs. high NLR group (NLR>2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9±149.7 µL vs. 192.5±127.7 µL, P=0.001, and 32.7±26.8 µL vs. 22.8±19.4 µL, P=0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P=0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P=0.050) and NLR>2.73 (OR, 1.848; 95% CI, 1.016-3.360, P=0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P=0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR. |
format | Online Article Text |
id | pubmed-4101783 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Academy of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-41017832014-07-18 Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis Choi, Yun Ha Hong, Young Joon Ahn, Youngkeun Park, In Hyae Jeong, Myung Ho J Korean Med Sci Original Article The aim of this study was to evaluate the relation between neutrophil-to-lymphocyte ratio (NLR) and plaque components assessed by virtual histology-intravascular ultrasound in 399 coronary artery disease (CAD) patients with 471 coronary lesions. We classified the lesions into two groups according to the NLR on admission {low NLR group (NLR≤2.73 [n=370]) vs. high NLR group (NLR>2.73 [n=101])}. By volumetric analysis, total atheroma and the absolute necrotic core (NC) volumes were significantly greater in high NLR group (249.9±149.7 µL vs. 192.5±127.7 µL, P=0.001, and 32.7±26.8 µL vs. 22.8±19.4 µL, P=0.001, respectively) and thin-cap fibroatheroma (TCFA) was observed more frequently in high NLR group (33% vs. 18%, P=0.001). ST segment elevation myocardial infarction (odds ratio [OR], 2.159; 95% CI, 1.000-4.660, P=0.050) and NLR>2.73 (OR, 1.848; 95% CI, 1.016-3.360, P=0.044) and total atheroma volume (OR, 1.003; 95% CI, 1.001-1.004, P=0.004) were the independent predictors of TCFA. CAD patients with high NLR had more vulnerable plaque components (greater NC-containing plaques) than those with low NLR. The Korean Academy of Medical Sciences 2014-07 2014-07-11 /pmc/articles/PMC4101783/ /pubmed/25045227 http://dx.doi.org/10.3346/jkms.2014.29.7.950 Text en © 2014 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Choi, Yun Ha Hong, Young Joon Ahn, Youngkeun Park, In Hyae Jeong, Myung Ho Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title | Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title_full | Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title_fullStr | Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title_full_unstemmed | Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title_short | Relationship between Neutrophil-to-Lymphocyte Ratio and Plaque Components in Patients with Coronary Artery Disease: Virtual Histology Intravascular Ultrasound Analysis |
title_sort | relationship between neutrophil-to-lymphocyte ratio and plaque components in patients with coronary artery disease: virtual histology intravascular ultrasound analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101783/ https://www.ncbi.nlm.nih.gov/pubmed/25045227 http://dx.doi.org/10.3346/jkms.2014.29.7.950 |
work_keys_str_mv | AT choiyunha relationshipbetweenneutrophiltolymphocyteratioandplaquecomponentsinpatientswithcoronaryarterydiseasevirtualhistologyintravascularultrasoundanalysis AT hongyoungjoon relationshipbetweenneutrophiltolymphocyteratioandplaquecomponentsinpatientswithcoronaryarterydiseasevirtualhistologyintravascularultrasoundanalysis AT ahnyoungkeun relationshipbetweenneutrophiltolymphocyteratioandplaquecomponentsinpatientswithcoronaryarterydiseasevirtualhistologyintravascularultrasoundanalysis AT parkinhyae relationshipbetweenneutrophiltolymphocyteratioandplaquecomponentsinpatientswithcoronaryarterydiseasevirtualhistologyintravascularultrasoundanalysis AT jeongmyungho relationshipbetweenneutrophiltolymphocyteratioandplaquecomponentsinpatientswithcoronaryarterydiseasevirtualhistologyintravascularultrasoundanalysis |