A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis

Atopic dermatitis (AD) is associated with the effects of Th2 and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating AD’s molecular changes; IL-17A’s role has yet to be defined. In this issue,...

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Autores principales: Dhingra, Nikhil, Guttman-Yassky, Emma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101909/
https://www.ncbi.nlm.nih.gov/pubmed/25029321
http://dx.doi.org/10.1038/jid.2014.141
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author Dhingra, Nikhil
Guttman-Yassky, Emma
author_facet Dhingra, Nikhil
Guttman-Yassky, Emma
author_sort Dhingra, Nikhil
collection PubMed
description Atopic dermatitis (AD) is associated with the effects of Th2 and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating AD’s molecular changes; IL-17A’s role has yet to be defined. In this issue, Nakajima et al. (2014) begin to define that role by demonstrating IL-17A’s ability to induce Th2 inflammation in acute disease.
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spelling pubmed-41019092015-02-01 A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis Dhingra, Nikhil Guttman-Yassky, Emma J Invest Dermatol Article Atopic dermatitis (AD) is associated with the effects of Th2 and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating AD’s molecular changes; IL-17A’s role has yet to be defined. In this issue, Nakajima et al. (2014) begin to define that role by demonstrating IL-17A’s ability to induce Th2 inflammation in acute disease. 2014-08 /pmc/articles/PMC4101909/ /pubmed/25029321 http://dx.doi.org/10.1038/jid.2014.141 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Dhingra, Nikhil
Guttman-Yassky, Emma
A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title_full A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title_fullStr A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title_full_unstemmed A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title_short A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis
title_sort possible role for il-17a in establishing th2 inflammation in murine models of atopic dermatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101909/
https://www.ncbi.nlm.nih.gov/pubmed/25029321
http://dx.doi.org/10.1038/jid.2014.141
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