Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in skeletal muscle. We show that SIRT1 transgenic muscle exhibits a fiber shift fr...

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Detalles Bibliográficos
Autores principales: Chalkiadaki, Angeliki, Igarashi, Masaki, Nasamu, Armiyaw Sebastian, Knezevic, Jovana, Guarente, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102452/
https://www.ncbi.nlm.nih.gov/pubmed/25032964
http://dx.doi.org/10.1371/journal.pgen.1004490

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