Endothelial Arginine Resynthesis Contributes to the Maintenance of Vasomotor Function in Male Diabetic Mice

AIM: Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation in normal and diabetic male mice. METHODS AND...

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Detalles Bibliográficos
Autores principales: Chennupati, Ramesh, Meens, Merlijn J. P. M. T., Marion, Vincent, Janssen, Ben J., Lamers, Wouter H., De Mey, Jo G. R., Köhler, S. Eleonore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102520/
https://www.ncbi.nlm.nih.gov/pubmed/25033204
http://dx.doi.org/10.1371/journal.pone.0102264

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