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T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

CD8+ T cell exhaustion represents a major hallmark of chronic HIV infection. Two key transcription factors governing CD8+ T cell differentiation, T-bet and Eomesodermin (Eomes), have previously been shown in mice to differentially regulate T cell exhaustion in part through direct modulation of PD-1....

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Detalles Bibliográficos
Autores principales:	Buggert, Marcus, Tauriainen, Johanna, Yamamoto, Takuya, Frederiksen, Juliet, Ivarsson, Martin A., Michaëlsson, Jakob, Lund, Ole, Hejdeman, Bo, Jansson, Marianne, Sönnerborg, Anders, Koup, Richard A., Betts, Michael R., Karlsson, Annika C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102564/ https://www.ncbi.nlm.nih.gov/pubmed/25032686 http://dx.doi.org/10.1371/journal.ppat.1004251

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