BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

While the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are thought to primarily depend on glycolysis for ATP synthesis, recent studies have shown that they can fully catabolize glucose in a canonical TCA cycle. However, these parasites lack a mitochondrial isoform of pyruvate d...

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Detalles Bibliográficos
Autores principales: Oppenheim, Rebecca D., Creek, Darren J., Macrae, James I., Modrzynska, Katarzyna K., Pino, Paco, Limenitakis, Julien, Polonais, Valerie, Seeber, Frank, Barrett, Michael P., Billker, Oliver, McConville, Malcolm J., Soldati-Favre, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102578/
https://www.ncbi.nlm.nih.gov/pubmed/25032958
http://dx.doi.org/10.1371/journal.ppat.1004263

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