Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis

The tumor suppressor protein prostate apoptosis response-4 (PAR-4) is silenced in a subset of human cancers and its down-regulation serves as a mechanism for cancer cell survival following chemotherapy. PAR-4 re-expression selectively causes apoptosis in cancer cells but how its pro-apoptotic functi...

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Detalles Bibliográficos
Autores principales: Treude, Fabian, Kappes, Ferdinand, Fahrenkamp, Dirk, Müller-Newen, Gerhard, Dajas-Bailador, Federico, Krämer, Oliver H., Lüscher, Bernhard, Hartkamp, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102785/
https://www.ncbi.nlm.nih.gov/pubmed/24931006

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