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Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer

RNF 180, a novel tumor suppressor, has been implicated in the carcinogenesis and progress of gastric cancer. At present study, we found that lower expression of RNA180 was specific in gastric cancer tissues, and the inconsistently methylated levels of RNF180 promoter were identified in the gastric c...

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Autores principales: Deng, Jingyu, Liang, Han, Ying, Guoguang, Zhang, Rupeng, Wang, Baogui, Yu, Jun, Fan, Daiming, Hao, Xishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102801/
https://www.ncbi.nlm.nih.gov/pubmed/24833402
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author Deng, Jingyu
Liang, Han
Ying, Guoguang
Zhang, Rupeng
Wang, Baogui
Yu, Jun
Fan, Daiming
Hao, Xishan
author_facet Deng, Jingyu
Liang, Han
Ying, Guoguang
Zhang, Rupeng
Wang, Baogui
Yu, Jun
Fan, Daiming
Hao, Xishan
author_sort Deng, Jingyu
collection PubMed
description RNF 180, a novel tumor suppressor, has been implicated in the carcinogenesis and progress of gastric cancer. At present study, we found that lower expression of RNA180 was specific in gastric cancer tissues, and the inconsistently methylated levels of RNF180 promoter were identified in the gastric cancer tissues. Importantly, we demonstrated that the methylated CpG site count and four hypermethylated CpG sites (−116, −80, +97, and +102) were significantly associated with the survival of 400 gastric cancer patients, respectively. With multivariate survival analyses, we demonstrated that both the methylation of combined CpG (−116, −80, +97, and +102) sites and N stage were the independent indictor of prognosis of gastric cancer patients. Eventually, the methylation of combined CpG (-116, -80, +97, and +102) sites was identified to have smaller AIC value than N stage by mean of AIC calculation with the Cox proportional hazards model. These findings indicated that the quantitative detection of RNF180 promoter methylation had the intensive feasibility for evaluation the prognosis of gastric cancer patients in clinic.
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spelling pubmed-41028012014-07-23 Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer Deng, Jingyu Liang, Han Ying, Guoguang Zhang, Rupeng Wang, Baogui Yu, Jun Fan, Daiming Hao, Xishan Oncotarget Research Paper RNF 180, a novel tumor suppressor, has been implicated in the carcinogenesis and progress of gastric cancer. At present study, we found that lower expression of RNA180 was specific in gastric cancer tissues, and the inconsistently methylated levels of RNF180 promoter were identified in the gastric cancer tissues. Importantly, we demonstrated that the methylated CpG site count and four hypermethylated CpG sites (−116, −80, +97, and +102) were significantly associated with the survival of 400 gastric cancer patients, respectively. With multivariate survival analyses, we demonstrated that both the methylation of combined CpG (−116, −80, +97, and +102) sites and N stage were the independent indictor of prognosis of gastric cancer patients. Eventually, the methylation of combined CpG (-116, -80, +97, and +102) sites was identified to have smaller AIC value than N stage by mean of AIC calculation with the Cox proportional hazards model. These findings indicated that the quantitative detection of RNF180 promoter methylation had the intensive feasibility for evaluation the prognosis of gastric cancer patients in clinic. Impact Journals LLC 2014-04-08 /pmc/articles/PMC4102801/ /pubmed/24833402 Text en Copyright: © 2014 Deng et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Deng, Jingyu
Liang, Han
Ying, Guoguang
Zhang, Rupeng
Wang, Baogui
Yu, Jun
Fan, Daiming
Hao, Xishan
Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title_full Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title_fullStr Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title_full_unstemmed Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title_short Methylation of CpG sites in RNF180 DNA promoter prediction poor survival of gastric cancer
title_sort methylation of cpg sites in rnf180 dna promoter prediction poor survival of gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102801/
https://www.ncbi.nlm.nih.gov/pubmed/24833402
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