SIAH2 antagonizes TYK2-STAT3 signaling in lung carcinoma cells

The Janus tyrosine kinases JAK1-3 and tyrosine kinase-2 (TYK2) are frequently hyperactivated in tumors. In lung cancers JAK1 and JAK2 induce oncogenic signaling through STAT3. A putative role of TYK2 in these tumors has not been reported. Here, we show a previously not recognized TYK2-STAT3 signalin...

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Detalles Bibliográficos
Autores principales: Müller, Sylvia, Chen, Yuan, Ginter, Torsten, Schäfer, Claudia, Buchwald, Marc, Schmitz, Lienhard M., Klitzsch, Jana, Schütz, Alexander, Haitel, Andrea, Schmid, Katharina, Moriggl, Richard, Kenner, Lukas, Friedrich, Karlheinz, Haan, Claude, Petersen, Iver, Heinzel, Thorsten, Krämer, Oliver H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102802/
https://www.ncbi.nlm.nih.gov/pubmed/24833526

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