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IRE1α knockdown rescues tunicamycin-induced developmental defects and apoptosis in Xenopus laevis

Inositol requiring enzyme-1 (IRE1) is highly conserved from yeasts to humans. Upon endoplasmic reticulum (ER) stress, IRE1 activates X-box-binding protein 1 (XBP1) by unconventional splicing of XBP1 mRNA, which activates unfolded protein response (UPR) to restore ER homeostasis. In mice, IRE1α plays...

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Detalles Bibliográficos
Autores principales:	Yuan, Li, Yu, Jin, Li, Xinxin, Feng, Jiaojiao, Yin, Chenyang, Wang, Xinru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editorial Department of Journal of Biomedical Research 2014
Materias:	Research-Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102841/ https://www.ncbi.nlm.nih.gov/pubmed/25050111 http://dx.doi.org/10.7555/JBR.28.20120075

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